Synthesis and antifungal activity of cholesterol-hydrazone derivatives

被引：278
作者：
Loncle, C
Brunel, JM
Vidal, N
Dherbomez, M
Letourneux, Y
机构：
[1] Univ Paul Cezanne, Fac Sci & Tech St Jerome, Lab Synth & Etude Subst Nat Activ Biol, IMRN,INRA 1111, F-13397 Marseille 20, France
[2] IUT La Rochelle, F-17026 La Rochelle, France
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 39卷 / 12期
关键词：
hydrazone; cholesterol derivatives; antifungal activity; antimicrobial activity;
D O I：
10.1016/j.ejmech.2004.07.005
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of hydrazones synthesized from various cholesterol derivatives were evaluated for their in vitro antimicrobial properties against human pathogens. The activity was highly dependent on the structure of the different compounds involved. The best results have been obtained with tosylhydrazone cholesterol derivatives 8 and 9 exhibiting activities against Candida albicans (CIP 1663-80) at a concentration of 1.5 mug/ml. (C) 2004 Elsevier SAS. All rights reserved.
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收藏
页码：1067 / 1071
页数：5
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