Drug-induced QT interval prolongation: Do we know the risks?

被引：1

作者：

Villamanan, Elena ^{[1
]}

Armada, Eduardo ^{[2
]}

Ruano, Margarita ^{[1
]}

机构：

[1] Hosp Univ La Paz, Serv Farm, Madrid, Spain

[2] Hosp Univ La Paz, Serv Cardiol, Madrid, Spain

来源：

MEDICINA CLINICA | 2015年 / 144卷 / 06期

关键词：

QT interval prolongation; Torsade de pointes; Drugs; Risk factors; Drug interactions; SUDDEN CARDIAC DEATH; TORSADE-DE-POINTES; ORAL ERYTHROMYCIN; MACROLIDE;

D O I：

10.1016/j.medcli.2014.01.027

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sudden cardiac death is an important cause of mortality in developed countries, most of them being consequence of acute ventricular arrhythmias. These arrhythmias, in some cases, owe to QT interval prolongation. A major risk factor for this condition is the use of drugs that prolong the QT interval. In fact, in recent years, one of the most common reasons for drug withdrawal or usage restrictions has been drug induced QT interval prolongation that involves both cardiovascular and non-cardiovascular drugs. Taking into account the severity that the occurrence of such an event may have, it is important for clinicians to know the risks of these drugs in certain patients. In this review we analyze the drugs that prolong the QT interval, the risk factors that can enhance QT prolongation and the drug interactions that can increase these risks. (C) 2013 Elsevier Espana, S.L.U. All rights reserved.

引用

页码：269 / 274

页数：6

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