MicroRNAs in central nervous system diseases: A prospective role in regulating blood-brain barrier integrity

被引：61
|
作者：
Ma, Feifei [1 ]
Zhang, Xuejing [1 ]
Yin, Ke-Jie [1 ,2 ]
机构：
[1] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh Inst Brain Disorders & Recovery, 200 Lothrop St,BST 5514, Pittsburgh, PA 15213 USA
[2] Vet Affairs Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA 15261 USA
来源：
EXPERIMENTAL NEUROLOGY | 2020年 / 323卷
基金：
美国国家卫生研究院;
关键词：
MicroRNAs; Central nervous system diseases; Blood-brain barrier; Vascular integrity; TUMOR BARRIER; CEREBRAL-ISCHEMIA; TIGHT JUNCTIONS; INTRACEREBRAL HEMORRHAGE; EXPRESSION CHANGES; STROKE OUTCOMES; IN-VITRO; PERMEABILITY; DYSFUNCTION; DISRUPTION;
D O I：
10.1016/j.expneurol.2019.113094
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Given the essential role of the blood-brain barrier (BBB) in the central nervous system (CNS), cumulative investigations have been performed to elucidate how modulation of BBB structural and functional integrity affects the pathogenesis of CNS diseases such as stroke, traumatic brain injuries, dementia, and cerebral infection. Recent studies have demonstrated that microRNAs (miRNAs) contribute to the maintenance of the BBB and thereby mediate CNS homeostasis. This review summarizes emerging studies that demonstrate cerebral miRNAs regulate BBB function in CNS disorders, emphasizing the direct role of miRNAs in BBB molecular composition. Evidence presented in this review will encourage a deeper understanding of the mechanisms by which miRNAs regulate BBB function, and facilitate the development of new miRNAs-based therapies in patients with CNS diseases.
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页数：11
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