Nano-organic supports for enzyme immobilization: Scopes and perspectives

被引：159

作者：

Zahirinejad, Sahar ^{[1
]}

Hemmati, Roohullah ^{[1
,2
]}

Homaei, Ahmad ^{[3
]}

Dinari, Ali ^{[4
]}

Hosseinkhani, Saman ^{[5
]}

Mohammadi, Soheila ^{[6
]}

Vianello, Fabio ^{[7
]}

机构：

[1] Shahrekord Univ, Fac Basic Sci, Dept Biol, Sharekord 3414188186, Iran

[2] Shahrekord Univ, Biotechnol Res Inst, Shahrekord, Iran

[3] Univ Hormozgan, Fac Marine Sci & Technol, Dept Marine Biol, Bandar Abbas, Iran

[4] Gwangju Inst Sci & Technol GIST, Res Ctr Nanorobot Brain, 123 Cheomdan Gwagiro, Bukgu 61005, South Korea

[5] Tarbiat Modares Univ, Fac Biol Sci, Dept Biochem, Tehran, Iran

[6] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Hlth Inst, Kermanshah, Iran

[7] Univ Padua, Dept Comparat Biomed & Food Sci, Padua, Italy

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2021年 / 204卷

关键词：

Enzyme immobilization; Nano-organic support; Hybrid support; Thermal stability; SITE-SPECIFIC IMMOBILIZATION; FUNCTIONALIZED MEMBRANES; ORIENTED IMMOBILIZATION; ALKALINE-PHOSPHATASE; CATALYTIC-ACTIVITY; CANDIDA-RUGOSA; LIPASE; STABILITY; LYSOZYME; NANOPARTICLES;

D O I：

10.1016/j.colsurfb.2021.111774

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A variety of organic nanomaterials and organic polymers are used for enzyme immobilization to increase enzymes stability and reusability. In this study, the effects of the immobilization of enzymes on organic and organic-inorganic hybrid nano-supports are compared. Immobilization of enzymes on organic support nanomaterials was reported to significantly improve thermal, pH and storage stability, acting also as a protection against metal ions inhibitory effects. In particular, the effects of enzyme immobilization on reusability, physical, kinetic and thermodynamic parameters were considered. Due to their biocompatibility with low health risks, organic support nanomaterials represent a good choice for the immobilization of enzymes. Organic nanomaterials, and especially organic-inorganic hybrids, can significantly improve the kinetic and thermodynamic parameters of immobilized enzymes compared to macroscopic supports. Moreover, organic nanomaterials are more environment friendly for medical applications, such as prodrug carriers and biosensors. Overall, organic hybrid nanomaterials are receiving increasing attention as novel nano-supports for enzyme immobilization and will be used extensively.

引用

页数：13

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