Rapid prototyping of cyclic olefin copolymer based microfluidic system with CO2 laser ablation

被引:21
作者
Cai, Jianchen [1 ]
Jiang, Jinyun [1 ]
Gao, Feng [2 ]
Jia, Guangnan [2 ]
Zhuang, Jian [2 ]
Tang, Gang [2 ]
Fan, Yiqiang [2 ]
机构
[1] Quzhou Univ, Coll Mech Engn, Quzhou 324000, Zhejiang, Peoples R China
[2] Beijing Univ Chem Technol, Coll Mech & Elect Engn, Beijing 100029, Peoples R China
来源
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS | 2017年 / 23卷 / 10期
基金
中国国家自然科学基金;
关键词
CHIP; DEVICE; CELLS; PDMS;
D O I
10.1007/s00542-017-3282-3
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Cyclic olefin copolymer (COC) has high chemical resistance with low water absorption and good optical transparency in visual and near UV range, which is a promising material for the polymer-based microfluidic systems. A comprehensive method for the rapid prototyping of COC based microfluidic system using CO2 laser ablation was proposed in this study. The COC substrate was fabricated by injection molding with a commercial injection molding machine, then CO2 laser was used for direct laser ablation of microchannels on the surface of COC substrate, to seal the laser ablated microchannels, the thermal compression bonding method for COC-based substrates was also provided in this research. The profile of the microchannels was carefully studied with different laser ablation power and scan speed, microfluidic device fabricated using the proposed method were also presented in this research.
引用
收藏
页码:5063 / 5069
页数:7
相关论文
共 23 条
[1]   Solid-phase extraction and purification of membrane proteins using a UV-modified PMMA microfluidic bioaffinity μSPE device [J].
Battle, Katrina N. ;
Jackson, Joshua M. ;
Witek, Malgorzata A. ;
Hupert, Mateusz L. ;
Hunsucker, Sally A. ;
Armistead, Paul M. ;
Soper, Steven A. .
ANALYST, 2014, 139 (06) :1355-1363
[2]   Rapid prototyping tools and methods for all-Topas® cyclic olefin copolymer fluidic microsystems [J].
Bundgaard, F. ;
Perozziello, G. ;
Geschke, O. .
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART C-JOURNAL OF MECHANICAL ENGINEERING SCIENCE, 2006, 220 (11) :1625-1632
[3]   An integrated microfluidic system for measurement of glycated hemoglobin Levels by using an aptamer-antibody assay on magnetic beads [J].
Chang, Ko-Wei ;
Li, Jinglun ;
Yang, Ching-Hsuan ;
Shiesh, Shu-Chu ;
Lee, Gwo-Bin .
BIOSENSORS & BIOELECTRONICS, 2015, 68 :397-403
[4]   Photolithographic surface micromachining of polydimethylsiloxane (PDMS) [J].
Chen, Weiqiang ;
Lam, Raymond H. W. ;
Fu, Jianping .
LAB ON A CHIP, 2012, 12 (02) :391-395
[5]   Application of metal film protection to microfluidic chip fabrication using CO2 laser ablation [J].
Chung, C. K. ;
Tu, K. Z. .
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS, 2014, 20 (10-11) :1987-1992
[6]   Rapid prototyping of PMMA microfluidic chips utilizing a CO2 laser [J].
Hong, Ting-Fu ;
Ju, Wei-Jhong ;
Wu, Ming-Chang ;
Tai, Chang-Hsien ;
Tsai, Chien-Hsiung ;
Fu, Lung-Ming .
MICROFLUIDICS AND NANOFLUIDICS, 2010, 9 (06) :1125-1133
[7]   Electrochemical detection of droplet contents in polystyrene microfluidic chip with integrated micro film electrodes [J].
Hu, Xianqiao ;
Lin, Xingyu ;
He, Qiaohong ;
Chen, Hengwu .
JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2014, 726 :7-14
[8]   Finger-powered microfluidic systems using multilayer soft lithography and injection molding processes [J].
Iwai, Kosuke ;
Shih, Kuan Cheng ;
Lin, Xiao ;
Brubaker, Thomas A. ;
Sochol, Ryan D. ;
Lin, Liwei .
LAB ON A CHIP, 2014, 14 (19) :3790-3799
[9]   Fabrication of polystyrene microfluidic devices using a pulsed CO2 laser system [J].
Li, Huawei ;
Fan, Yiqiang ;
Kodzius, Rimantas ;
Foulds, Ian G. .
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS, 2012, 18 (03) :373-379
[10]   Measuring transport properties of cell membranes by a PDMS microfluidic device with controllability over changing rate of extracellular solution [J].
Lyu, Shaw-Ruey ;
Chen, Wun-Jie ;
Hsieh, Wen-Hsin .
SENSORS AND ACTUATORS B-CHEMICAL, 2014, 197 :28-34