Tonin in rat heart with experimental hypertrophy

被引:14
|
作者
Borges, JC
Silva, JA
Gomes, MA
Lomez, ESL
Leite, KM
Araujo, RC
Bader, M
Pesquero, JB
Pesquero, JL
机构
[1] Univ Fed Minas Gerais, Inst Biol Sci, Dept Physiol & Biophys, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Parasitol, BR-31270901 Belo Horizonte, MG, Brazil
[3] Univ Fed Sao Paulo, Dept Biophys, BR-04023062 Sao Paulo, Brazil
[4] Univ Mogi das Cruzes, BR-08789091 Mogi Das Cruzes, Brazil
[5] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2003年 / 284卷 / 06期
关键词
angiotensin II; isoproterenol; growth myocardium; renin; angiotensinogen;
D O I
10.1152/ajpheart.00416.2002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The present study was undertaken to determine tonin expression and activity in rat heart presenting isoproterenol-induced hypertrophy. Renin, angiotensin-converting enzyme (ACE), and angiotensinogen (AG) expression were also determined. Wistar rats were treated with isoproterenol for 7 days (5 mg.kg(-1).day(-1) sc). For untreated animals, the levels of tonin-specific activity in the atrium were 2.6- and 5.5-fold higher than those of the left and right ventricle, respectively. After treatment, the levels of tonin-specific activity increased twofold in the atrium but did not change in the ventricles. Renin expression was not detectable in these structures, and ACE expression levels did not change with treatment. AG expression was detected in the left ventricle at very low levels compared with the atrium and increased significantly only in the hypertrophied atrium (1.8-fold). Tonin mRNA was not detected in the ventricle but was found at low levels in the atrium, which increased after isoproterenol treatment. Our results permit us to conclude that tonin may play a role in the process of heart hypertrophy in the rat.
引用
收藏
页码:H2263 / H2268
页数:6
相关论文
共 50 条
  • [21] EXPERIMENTAL RENAL HYPERTROPHY INDUCED BY SURAMIN IN THE RAT
    SELMECI, L
    POSCH, E
    VASADI, P
    HARSING, L
    ACTA PHYSIOLOGICA ACADEMIAE SCIENTIARUM HUNGARICAE, 1978, 52 (2-3): : 319 - 319
  • [22] KINETIC-STUDIES OF RAT RENIN AND TONIN ON PURIFIED RAT ANGIOTENSINOGEN
    GUTKOWSKA, J
    CORVOL, P
    FIGUEIREDO, AFS
    INAGAMI, T
    BOUHNIK, J
    GENEST, J
    CANADIAN JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY, 1984, 62 (2-3): : 137 - 142
  • [23] INTRACEULLAR PH OF RAT-HEART IN CHRONIC HYPERTROPHY
    HERTEN, W
    ALBERS, C
    KLINISCHE WOCHENSCHRIFT, 1976, 54 (01): : 43 - 43
  • [24] AUTORADIOGRAPHIC STUDY OF DNA SYNTHESIS IN HEART HYPERTROPHY OF RAT
    NORMAN, TD
    FOSTER, MA
    FEDERATION PROCEEDINGS, 1963, 22 (02) : 194 - &
  • [25] PPARg activation reduces hypertrophy in the hyperthyroid RAT heart
    Heather, LC
    Leoni, RP
    Cole, MA
    Clarke, K
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2005, 38 (06) : 1027 - 1028
  • [26] NUCLEIC ACID SYNTHESIS IN RAT HEART DURING HYPERTROPHY
    KAKO, KJ
    FRENCH, I
    BEZNAK, M
    CIRCULATION, 1969, 40 (4S3) : I117 - +
  • [28] ROLE OF THE PITUITARY IN THE EFFECTS OF TONIN ON ADRENAL SECRETION OF THE RAT
    SCHIFFRIN, EL
    GARCIA, R
    GUTKOWSKA, J
    GENEST, J
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1983, 61 (03) : 201 - 206
  • [29] MORPHOMETRY OF HEART-MUSCLE IN EXPERIMENTAL EXERCISE HYPERTROPHY
    MATTFELDT, T
    KRAMER, KL
    ZEITZ, R
    MALL, G
    ZEITSCHRIFT FUR KARDIOLOGIE, 1985, 74 : 19 - 19
  • [30] PROTEIN SYNTHESIS IN MYOCARDIAL HYPERTROPHY AND EXPERIMENTAL HEART FAILURE
    GUDBJARNASON, S
    BING, RJ
    TELERMAN, M
    FEDERATION PROCEEDINGS, 1963, 22 (02) : 345 - &