Nanomechanics of individual amyloid fibrils using atomic force microscopy

被引：9

作者：

Zhou XingFei ^{[1
]}

Cui ChengYi ^{[1
]}

Zhang JinHai ^{[1
]}

Liu JianHua ^{[1
]}

Liu JingSong ^{[1
]}

机构：

[1] Ningbo Univ, Coll Sci, Nanomat Lab, Ningbo 315211, Zhejiang, Peoples R China

来源：

CHINESE SCIENCE BULLETIN | 2010年 / 55卷 / 16期

基金：

中国国家自然科学基金;

关键词：

amyloid fibrils; nanoindentation; AFM; elastic modulus; GLUCAGON FIBRILLATION; RADIAL COMPRESSION; ELASTIC PROPERTIES; POLYMORPHISM; NANOTUBES;

D O I：

10.1007/s11434-010-3201-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Compression elasticity of glucagon amyloid fibrils in the transverse direction was investigated by a nanoindentation approach based on atomic force microscopy (AFM). With force-volume mapping, we obtained the correlations between radially applied force and compression of amyloid fibrils, from which the radial compressive elasticity can be deduced. The estimated elastic modulus at three typical locations of fibrils varied from (0.72 +/- 0.80) GPa to (1.26 +/- 0.62) GPa under small external forces, implying the structural heterogeneity of different fibrils.

引用

页码：1608 / 1612

页数：5

共 50 条

[31] Atomic Force Microscopy: The Characterisation of Amyloid Protein Structure in Pathology
Visser, Maria J. E.
Pretorius, Etheresia
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2019, 19 (32) : 2958 - 2973
[32] Atomic force microscopy 3D structural reconstruction of individual particles in the study of amyloid protein assemblies
Chitty, Claudia
Kuliga, Kinga
Xue, Wei-Feng
BIOCHEMICAL SOCIETY TRANSACTIONS, 2024, 52 (02) : 761 - 771
[33] Near-Surface Nanomechanics of Medical-Grade PEEK Measured by Atomic Force Microscopy
Bontempi, Marco
Capozza, Rosario
Visani, Andrea
Fini, Milena
Giavaresi, Gianluca
Gambardella, Alessandro
POLYMERS, 2023, 15 (03)
[34] Unusual architecture of the exceedingly tough Macadamia "nut"-shell as revealed by atomic force microscopy and nanomechanics
Naimi-Jamal, M. R.
Kaupp, G.
INTERNATIONAL JOURNAL OF MATERIALS RESEARCH, 2007, 98 (05) : 438 - 445
[35] Study of the Mullins Effect in Carbon Black-Filled Styrene-Butadiene Rubber by Atomic Force Microscopy Nanomechanics
Liang, Xiaobin
Nakajima, Ken
MACROMOLECULES, 2022, 55 (14) : 6023 - 6030
[36] VERIFICATION OF NANOINDENTATION DEVICES USING ATOMIC FORCE MICROSCOPY
Charvatova Campbell, Anna
Havlicek, Marek
Klapetek, Petr
Bursikova, Vilma
11TH INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2019), 2020, : 698 - 703
[37] Determination of silicone coating Young's modulus using atomic force microscopy
Thome, T.
Fouchez, S.
Delalande, S.
PHYSICA B-CONDENSED MATTER, 2009, 404 (01) : 22 - 25
[38] Imaging the Substructures of Individual IgE Antibodies with Atomic Force Microscopy
Hu, Jing
Gao, Mingyan
Wang, Ying
Liu, Mengnan
Wang, Jianfei
Li, Jiani
Song, Zhengxun
Chen, Yujuan
Wang, Zuobin
LANGMUIR, 2019, 35 (46) : 14896 - 14901
[39] The study on the micromechanical mechanism of PP/EPDM blends and PP/SEBS blends using atomic force microscopy-based nanomechanics
Hanai, Mari
Ito, Makiko
Liang, Xiaobin
Nakajima, Ken
JAPANESE JOURNAL OF APPLIED PHYSICS, 2024, 63 (07)
[40] Nanolithography of Amyloid Precursor Protein Cleavage with β-Secretase by Atomic Force Microscopy
Han, Sung-Woong
Shin, Hoon-Kyu
Adachi, Taiji
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2016, 12 (03) : 546 - 553

← 1 2 3 4 5 →