Nanomechanics of individual amyloid fibrils using atomic force microscopy

被引：9

作者：

Zhou XingFei ^{[1
]}

Cui ChengYi ^{[1
]}

Zhang JinHai ^{[1
]}

Liu JianHua ^{[1
]}

Liu JingSong ^{[1
]}

机构：

[1] Ningbo Univ, Coll Sci, Nanomat Lab, Ningbo 315211, Zhejiang, Peoples R China

来源：

CHINESE SCIENCE BULLETIN | 2010年 / 55卷 / 16期

基金：

中国国家自然科学基金;

关键词：

amyloid fibrils; nanoindentation; AFM; elastic modulus; GLUCAGON FIBRILLATION; RADIAL COMPRESSION; ELASTIC PROPERTIES; POLYMORPHISM; NANOTUBES;

D O I：

10.1007/s11434-010-3201-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Compression elasticity of glucagon amyloid fibrils in the transverse direction was investigated by a nanoindentation approach based on atomic force microscopy (AFM). With force-volume mapping, we obtained the correlations between radially applied force and compression of amyloid fibrils, from which the radial compressive elasticity can be deduced. The estimated elastic modulus at three typical locations of fibrils varied from (0.72 +/- 0.80) GPa to (1.26 +/- 0.62) GPa under small external forces, implying the structural heterogeneity of different fibrils.

引用

页码：1608 / 1612

页数：5

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