Combinatorial Oxytocin Neuropharmacology in Social Cognition

被引:12
作者
Fan, Siqi [1 ]
Weinberg-Wolf, Hannah [1 ]
Piva, Matthew [1 ]
Dal Monte, Olga [1 ,2 ]
Chang, Steve W. C. [1 ,3 ,4 ]
机构
[1] Yale Univ, Dept Psychol, New Haven, CT 06520 USA
[2] Univ Turin, Dept Psychol, Turin, Italy
[3] Yale Univ, Sch Med, Dept Neurosci, 333 Cedar St, New Haven, CT 06520 USA
[4] Yale Univ, Sch Med, Kavli Inst Neurosci, 333 Cedar St, New Haven, CT 06520 USA
关键词
SEROTONIN; SECRETION;
D O I
10.1016/j.tics.2019.10.004
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The efficacy and reliability of using intranasal oxytocin (OT) to clinically enhance social functions remains undependable. We discuss the potential benefit of concurrent administration of OT and naloxone (NAL) to robustly modulate social behavior. We further suggest that combinatorial neuropharmacology approaches should exploit the interactions between OT and serotonin to regulate social functions.
引用
收藏
页码:8 / 12
页数:6
相关论文
共 12 条
[1]   Involvement of Serotonin and Oxytocin in Neural Mechanism Regulating Amicable Social Signal in Male Mice: Implication for Impaired Recognition of Amicable Cues in BALB/c Strain [J].
Arakawa, Hiroyuki .
BEHAVIORAL NEUROSCIENCE, 2017, 131 (02) :176-191
[2]   ENDOGENOUS OPIATES REGULATE OXYTOCIN BUT NOT VASOPRESSIN SECRETION FROM THE NEUROHYPOPHYSIS [J].
BICKNELL, RJ ;
LENG, G .
NATURE, 1982, 298 (5870) :161-162
[3]  
BICKNELL RJ, 1985, EXP BRAIN RES, V60, P192
[4]   Oxytocin under opioid antagonism leads to supralinear enhancement of social attention [J].
Dal Monte, Olga ;
Piva, Matthew ;
Anderson, Kevin M. ;
Tringides, Marios ;
Holmes, Avram J. ;
Chang, Steve W. C. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (20) :5247-5252
[5]   Examining Autism Spectrum Disorders by Biomarkers: Example From the Oxytocin and Serotonin Systems [J].
Hammock, Elizabeth ;
Veenstra-VanderWeele, Jeremy ;
Yan, Zhongyu ;
Kerr, Travis M. ;
Morris, Marianna ;
Anderson, George M. ;
Carter, C. Sue ;
Cook, Edwin H. ;
Jacob, Suma .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2012, 51 (07) :712-721
[6]   Oxytocin Fails to Recruit Serotonergic Neurotransmission in the Autistic Brain [J].
Lefevre, Arthur ;
Mottolese, Raphaelle ;
Redoute, Jerome ;
Costes, Nicolas ;
Le Bars, Didier ;
Geoffray, Marie-Maude ;
Leboyer, Marion ;
Sirigu, Angela .
CEREBRAL CORTEX, 2018, 28 (12) :4169-4178
[7]   Switching brain serotonin with oxytocin [J].
Mottolese, Raphaelle ;
Redoute, Jerome ;
Costes, Nicolas ;
Le Bars, Didier ;
Sirigu, Angela .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (23) :8637-8642
[8]   Bridging the gap between rodents and humans: The role of non-human primates in oxytocin research [J].
Putnam, Philip T. ;
Young, Larry J. ;
Gothard, Katalin M. .
AMERICAN JOURNAL OF PRIMATOLOGY, 2018, 80 (10)
[9]   THE EFFECTS OF MORPHINE, NALOXONE, AND κ OPIOID MANIPULATION ON ENDOCRINE FUNCTIONING AND SOCIAL BEHAVIOR IN MONOGAMOUS TITI MONKEYS (CALLICEBUS CUPREUS) [J].
Ragen, B. J. ;
Maninger, N. ;
Mendoza, S. P. ;
Bales, K. L. .
NEUROSCIENCE, 2015, 287 :32-42
[10]   Differences in how macaques monitor others: Does serotonin play a central role? [J].
Weinberg-Wolf, Hannah ;
Chang, Steve W. C. .
WILEY INTERDISCIPLINARY REVIEWS-COGNITIVE SCIENCE, 2019, 10 (04)