Antioxidant enzyme activity in rat hippocampus after chronic and acute stress exposure

被引:10
|
作者
Stojiljkovic, V [1 ]
Todorovic, A [1 ]
Kasapovic, J [1 ]
Pejic, S [1 ]
Pajovic, SB [1 ]
机构
[1] Inst Nucl Sci Vinca, Lab Mol Biol & Endocrinol, Belgrade 11001, Serbia Monteneg
来源
BIOPHYSICS FROM MOLECULES TO BRAIN: IN MEMORY OF RADOSLAV K. ANDJUS | 2005年 / 1048卷
关键词
rat; hippocampus; stress; superoxide dismutase; catalase;
D O I
10.1196/annals.1342.042
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Chronic exposure to stress alters the prooxidant-antioxidant balance, which might lead to the development of various human pathological states. In order to explain the role of antioxidant response in stress-induced injury, we examined the effects of two types of acute stress, as well as combined effects of chronic and acute stress on manganese-superoxide dismutase, copper,zinc-superoxide dismutase, and catalase activities in rat brain hippocampus. Our results show that chronic stress induces an increase in oxidative enzyme activities and that adaptation to chronic stress might alter hippocampal antioxidant mechanisms' response to acute stress.
引用
收藏
页码:373 / 376
页数:4
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