Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor

被引：37

作者：

Hillerns, PI ^{[1
]}

Wink, M ^{[1
]}

机构：

[1] Heidelberg Univ, Inst Pharm & Mol Biotechnol, D-69120 Heidelberg, Germany

来源：

PLANTA MEDICA | 2005年 / 71卷 / 11期

关键词：

D O I：

10.1055/s-2005-871302

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Prenylflavonoids and lavandulylflavonoids were isolated from the roots of Sophora flavescens Aiton (Fabaceae). The ability of 8-prenylkaempferol (1), kushenol X (2), norkurarinone (3), leachianone A (4), kushenol C (5), maackiain (6) and a root-extract of S. flavescens to displace 17 beta-estradiol (E2) from rat uterine estrogen receptor (ER) was determined. Relative binding affinities (RBA) of prenylated flavonoids were weak with RBA values between 0.004 and 0.072. A lavandulyl or prenyl group at the position 8 enhanced binding to rat uterine ER.

引用

页码：1065 / 1068

页数：4

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