Determination of endocrine-disrupting compounds in water samples by magnetic nanoparticle-assisted dispersive liquid-liquid microextraction combined with gas chromatography-tandem mass spectrometry

被引:22
作者
Ana Perez, Rosa [1 ]
Albero, Beatriz [1 ]
Luis Tadeo, Jose [1 ]
Sanchez-Brunete, Consuelo [1 ]
机构
[1] Inst Nacl Invest & Tecnol Agr & Alimentaria INIA, Dept Medio Ambiente, Carretera Coruna 7, Madrid 28040, Spain
关键词
Dispersive liquid-liquid microextraction; Magnetic nanoparticles; Endocrine-disrupting compounds; Waters; Gas chromatography-tandem mass spectrometry; SOLID-PHASE EXTRACTION; ENVIRONMENTAL WATER; ULTRAVIOLET FILTERS; STEROID-HORMONES; ESTROGENIC ACTIVITY; PHENOLIC-COMPOUNDS; PRECONCENTRATION; SILYLATION; SOLIDIFICATION; OPTIMIZATION;
D O I
10.1007/s00216-016-9899-8
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A rapid extraction procedure is presented for the determination of five endocrine-disrupting compounds, estrone, ethinylestradiol, bisphenol A, triclosan, and 2-ethylhexylsalicylate, in water samples. The analysis involves a two-step extraction procedure that combines dispersive liquid-liquid microextraction (DLLME) with dispersive micro-solid phase extraction (D-mu-SPE), using magnetic nanoparticles, followed by in situ derivatization in the injection port of a gas chromatograph coupled to triple quadrupole mass spectrometry. The use of uncoated or oleate-coated Fe3O4 nanoparticles as sorbent in the extraction process was evaluated and compared. The main parameters involved in the extraction process were optimized applying experimental designs. Uncoated Fe3O4 nanoparticles were selected in order to simplify and make more cost-effective the procedure. DLLME was carried out at pH 3, during 2 min, followed by the addition of the nanoparticles for D-mu-SPE employing 1 min in the extraction. Analysis of spiked water samples of different sources gave satisfactory recovery results for all the compounds with detection limits ranging from 7 to 180 ng l(-1). Finally, the procedure was applied in tap, well, and river water.
引用
收藏
页码:8013 / 8023
页数:11
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