Inhibitory effects of alpha-zearalenol on angiotensin II-induced integrin β3 mRNA via suppression of nuclear factor-κB

被引：0
|
作者：
Li, SM [1 ]
Wang, XM [1 ]
Qiu, J [1 ]
Si, Q [1 ]
Guo, HY [1 ]
Sun, RY [1 ]
Wu, QX [1 ]
机构：
[1] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Pathophysiol, Sch Basic Med,Peking Union Med Coll, Beijing 100005, Peoples R China
来源：
BIOMEDICAL AND ENVIRONMENTAL SCIENCES | 2005年 / 18卷 / 05期
关键词：
alpha-zearalenol; integrin beta(3); endothelial cell; NF-kappa B; 17; beta-estradiol;
D O I：
暂无
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Objective: To investigate the effect of a-zearalenol on angiotensin H-induced beta(3) integrin mRNA expression in human umbilical vein endothelial cells (HUVECs). Methods: The mRNA level in integrin beta(3) was determined by reverse transcription-polymerase chain reaction. Endothelial NF-kappa B activity was determined by the luciferase activity assay of plasmid NF-kappa B-LUC. Results: The angiotensin II-induced beta(3) integrin mRNA expression was inhibited by alpha-zearalenol and 17 beta-estradiol (10 nmol/L -1 mu mol/L), but not influenced by ICI 182, 780, a pure competitive antagonist for estrogen receptor or a nitric oxide inhibitor N-omega-Nitro-L-arginine methyl ester hydrochloride. Alpha-zearalenol and 17 beta-estradiol suppressed the angiotensin II-induced activation of NF-kappa B in endothelial cells. Conclusion: Alpha-zearalenol inhibits angiotensin II-induced integrin beta(3) mRNA expression by suppressing NF-kappa B activation in endothelial cells.
引用
收藏
页码：314 / 320
页数：7
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