Inhibitory effects of alpha-zearalenol on angiotensin II-induced integrin β3 mRNA via suppression of nuclear factor-κB

被引：0

作者：

Li, SM ^{[1
]}

Wang, XM ^{[1
]}

Qiu, J ^{[1
]}

Si, Q ^{[1
]}

Guo, HY ^{[1
]}

Sun, RY ^{[1
]}

Wu, QX ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Pathophysiol, Sch Basic Med,Peking Union Med Coll, Beijing 100005, Peoples R China

来源：

BIOMEDICAL AND ENVIRONMENTAL SCIENCES | 2005年 / 18卷 / 05期

关键词：

alpha-zearalenol; integrin beta(3); endothelial cell; NF-kappa B; 17; beta-estradiol;

D O I：

暂无

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Objective: To investigate the effect of a-zearalenol on angiotensin H-induced beta(3) integrin mRNA expression in human umbilical vein endothelial cells (HUVECs). Methods: The mRNA level in integrin beta(3) was determined by reverse transcription-polymerase chain reaction. Endothelial NF-kappa B activity was determined by the luciferase activity assay of plasmid NF-kappa B-LUC. Results: The angiotensin II-induced beta(3) integrin mRNA expression was inhibited by alpha-zearalenol and 17 beta-estradiol (10 nmol/L -1 mu mol/L), but not influenced by ICI 182, 780, a pure competitive antagonist for estrogen receptor or a nitric oxide inhibitor N-omega-Nitro-L-arginine methyl ester hydrochloride. Alpha-zearalenol and 17 beta-estradiol suppressed the angiotensin II-induced activation of NF-kappa B in endothelial cells. Conclusion: Alpha-zearalenol inhibits angiotensin II-induced integrin beta(3) mRNA expression by suppressing NF-kappa B activation in endothelial cells.

引用

页码：314 / 320

页数：7

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