Effect of the addition of rituximab to salvage chemotherapy prior to autologous stem cell transplant in aggressive CD20+lymphoma: a cohort comparison from the NCIC Clinical Trials Group Study LY.12

被引：10

作者：

Baetz, Tara ^{[1
]}

Chen, Bingshu E. ^{[2
]}

Couban, Stephen ^{[3
]}

Kouroukis, C. Tom ^{[4
]}

Buckstein, Rena ^{[5
]}

Kuruvilla, John ^{[6
]}

Howson-Jan, Kang ^{[7
]}

Szwajcer, David ^{[8
]}

Federico, Massimo ^{[9
]}

Meyer, Ralph M. ^{[4
]}

Djurfeldt, Marina S. ^{[2
]}

Hay, Annette E. ^{[2
]}

Shepherd, Lois ^{[2
]}

Crump, Michael ^{[6
]}

机构：

[1] Queens Univ, Canc Ctr Southeastern Ontario, Dept Oncol, Kingston, ON, Canada

[2] Queens Univ, Canc Res Inst, Canadian Canc Trials Grp, Kingston, ON, Canada

[3] Queen Elizabeth II Heath Sci Ctr, Halifax, NS, Canada

[4] Juravinski Hosp & Canc Ctr, Dept Oncol, Hamilton, ON, Canada

[5] Univ Toronto, Sunnybrook Hlth Sci Ctr, Odette Canc Ctr, Dept Hematol Oncol, Toronto, ON, Canada

[6] Univ Toronto, Princess Margaret Canc Ctr, Div Med Oncol & Hematol, Toronto, ON, Canada

[7] London Hlth Sci Ctr, London, ON, Canada

[8] Univ Manitoba, Dept Med, Winnipeg, MB, Canada

[9] Univ Modena & Reggio Emilia, Cattedra Oncol Med, Modena, Italy

来源：

LEUKEMIA & LYMPHOMA | 2017年 / 58卷 / 01期

关键词：

Autologous transplant; rituximab; salvage chemotherapy; ELDERLY-PATIENTS; PLUS RITUXIMAB; LYMPHOMA; COMBINATION; CHOP; DHAP; GEMCITABINE; CISPLATIN; ICE;

D O I：

10.1080/10428194.2016.1187274

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The impact of the addition of rituximab to salvage chemotherapy prior to autologous stem cell transplant (ASCT) was evaluated in a retrospective subgroup analysis of NCIC CTG LY. 12. Among 414 patients who relapsed following R-CHOP, 96 received salvage chemotherapy alone [R + cohort]; and 318 received rituximab with chemotherapy [R-cohort] following a protocol amendment. The R-cohort had a higher proportion of patients with PS >= 2 and relapse < 1 year after RCHOP. The response rate (45.6% vs. 25.0%, p = 0.0003), CR/CRu (15.7% vs. 4.2%, p = 0.003) and transplantation rate (51.9% vs. 31.3%, p = 0.0004) was higher in the R-cohort. Event-free (27% vs. 22%, p = 0.0954) and overall survival at four years (43% vs. 31%; p = 0.045) were greater in the R-cohort when the patients with best response SD/PD to R-CHOP were excluded. Addition of rituximab to salvage therapy before ASCT appears to improve the response rate, transplantation rate, and overall survival in patients with CD20+ lymphoma who responded to R-CHOP.

引用

页码：64 / 69

页数：6

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