Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats

被引：88
|
作者：
Tang, Lixia [1 ]
Li, Ke [1 ]
Zhang, Yan [2 ]
Li, Huifang [1 ]
Li, Ankang [3 ]
Xu, Yuancheng [4 ]
Wei, Bing [5 ]
机构：
[1] First Peoples Hosp Yongkang, Dept Endocrine, Jinhua 321300, Zhejiang, Peoples R China
[2] Zhucheng Maternal & Child Hlth Hosp, Dept Pathol, Weifang 262200, Peoples R China
[3] First Peoples Hosp Yongkang, Dept Pharm, Jinhua 321300, Zhejiang, Peoples R China
[4] First Peoples Hosp Yongkang, Dept Pathol, Jinhua 321300, Zhejiang, Peoples R China
[5] First Peoples Hosp Yongkang, Dept Orthoped, Jinhua 321300, Zhejiang, Peoples R China
来源：
SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期
关键词：
DNA-DAMAGE; IN-VITRO; MANAGEMENT; INSULIN; BIOAVAILABILITY; HYPERGLYCEMIA; PIOGLITAZONE; NANOPARTICLE; RESVERATROL; TRANSITION;
D O I：
10.1038/s41598-020-59411-7
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The effects of quercetin liposomes (Q-PEGL) on streptozotocin (STZ)-induced diabetic nephropathy (DN) was investigated in rats. Male Sprague Dawley rats were used to establish a STZ induced DN model. DN rats randomly received one of the following treatments for 8 weeks: blank treatment (DN), free quercetin (Que), pegylated liposomes (PEGL) and pegylated quercetin liposomes (Q-PEGL). A group of healthy rats served as the normal control. The fasting blood glucose (FBG), body weights (BWs), renal hypertrophy index (rHI), serum and urine biochemistry, renal histopathology, oxidative stress and immunohistochemical measurements of AGEs were analyzed to compare the effect of different treatments. Que and Q-PEGL significantly improved DN biochemistry and pathological changes, although the treated rats still had some symptoms of DN. The therapeutic effect of Q-PEGL surpassed that of Que. Pegylated quercetin liposomes allow maintaining higher quercetin concentrations in plasma than non-encapsulated quercetin. In conclusion the use of quercetin liposomes allows to reduce disease symptoms in a rat model of DN.
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页数：8
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