Hydropersulfides (RSSH) and Nitric Oxide (NO) Signaling: Possible Effects on S-Nitrosothiols (RS-NO)

被引：11

作者：

Fukuto, Jon M. ^{[1
,2
]}

Perez-Ternero, Cristina ^{[3
]}

Zarenkiewicz, Jessica ^{[1
]}

Lin, Joseph ^{[4
]}

Hobbs, Adrian J. ^{[3
]}

Toscano, John P. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem, Charles & 34th St, Baltimore, MD 21218 USA

[2] Sonoma State Univ, Dept Chem, Rohnert Pk, CA 94928 USA

[3] Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med, Charterhouse Sq, London EC1M 6BQ, England

[4] Sonoma State Univ, Dept Biol, Rohnert Pk, CA 94928 USA

来源：

ANTIOXIDANTS | 2022年 / 11卷 / 01期

基金：

美国国家科学基金会;

关键词：

S-nitrosothiol; hydropersulfide; nitric oxide; nitroxyl; perthiyl radical; HYDROGEN-SULFIDE; ASCORBIC-ACID; CHEMICAL BIOLOGY; IRON(III) PORPHYRINS; CYSTEINE PERSULFIDES; NITROXYL HNO; NITROSYLATION; CHEMISTRY; MECHANISM; KINETICS;

D O I：

10.3390/antiox11010169

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

S-Nitrosothiol (RS-NO) formation in proteins and peptides have been implicated as factors in the etiology of many diseases and as possible regulators of thiol protein function. They have also been proposed as possible storage forms of nitric oxide (NO). However, despite their proposed functions/roles, there appears to be little consensus regarding the physiological mechanisms of RS-NO formation and degradation. Hydropersulfides (RSSH) have recently been discovered as endogenously generated species with unique reactivity. One important reaction of RSSH is with RS-NO, which leads to the degradation of RS-NO as well as the release of NO. Thus, it can be speculated that RSSH can be a factor in the regulation of steady-state RS-NO levels, and therefore may be important in RS-NO (patho)physiology. Moreover, RSSH-mediated NO release from RS-NO may be a possible mechanism allowing RS-NO to serve as a storage form of NO.

引用

页数：18

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