Hydropersulfides (RSSH) and Nitric Oxide (NO) Signaling: Possible Effects on S-Nitrosothiols (RS-NO)

被引：11

作者：

Fukuto, Jon M. ^{[1
,2
]}

Perez-Ternero, Cristina ^{[3
]}

Zarenkiewicz, Jessica ^{[1
]}

Lin, Joseph ^{[4
]}

Hobbs, Adrian J. ^{[3
]}

Toscano, John P. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem, Charles & 34th St, Baltimore, MD 21218 USA

[2] Sonoma State Univ, Dept Chem, Rohnert Pk, CA 94928 USA

[3] Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med, Charterhouse Sq, London EC1M 6BQ, England

[4] Sonoma State Univ, Dept Biol, Rohnert Pk, CA 94928 USA

来源：

ANTIOXIDANTS | 2022年 / 11卷 / 01期

基金：

美国国家科学基金会;

关键词：

S-nitrosothiol; hydropersulfide; nitric oxide; nitroxyl; perthiyl radical; HYDROGEN-SULFIDE; ASCORBIC-ACID; CHEMICAL BIOLOGY; IRON(III) PORPHYRINS; CYSTEINE PERSULFIDES; NITROXYL HNO; NITROSYLATION; CHEMISTRY; MECHANISM; KINETICS;

D O I：

10.3390/antiox11010169

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

S-Nitrosothiol (RS-NO) formation in proteins and peptides have been implicated as factors in the etiology of many diseases and as possible regulators of thiol protein function. They have also been proposed as possible storage forms of nitric oxide (NO). However, despite their proposed functions/roles, there appears to be little consensus regarding the physiological mechanisms of RS-NO formation and degradation. Hydropersulfides (RSSH) have recently been discovered as endogenously generated species with unique reactivity. One important reaction of RSSH is with RS-NO, which leads to the degradation of RS-NO as well as the release of NO. Thus, it can be speculated that RSSH can be a factor in the regulation of steady-state RS-NO levels, and therefore may be important in RS-NO (patho)physiology. Moreover, RSSH-mediated NO release from RS-NO may be a possible mechanism allowing RS-NO to serve as a storage form of NO.

引用

页数：18

共 50 条

[11] Conversion of nitrite to nitric oxide at zinc via S-nitrosothiols
Cardenas, Allan Jay P.
Abelman, Rebecca
Warren, Timothy H.
CHEMICAL COMMUNICATIONS, 2014, 50 (02) : 168 - 170
[12] S-nitrosothiols:: a class of nitric oxide-donor drugs
Al-Sa'doni, H
Ferro, A
CLINICAL SCIENCE, 2000, 98 (05) : 507 - 520
[13] S-nitrosothiols as nitric oxide-donors:: Chemistry, biology and possible future therapeutic applications
Al-Sa'doni, HH
Ferro, A
CURRENT MEDICINAL CHEMISTRY, 2004, 11 (20) : 2679 - 2690
[14] Unprecedented External Electric Field Effects on S-Nitrosothiols: Possible Mechanism of Biological Regulation?
Timerghazin, Qadir K.
Talipov, Marat R.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2013, 4 (06): : 1034 - 1038
[15] Synthesis and nitric oxide releasing properties of novel fluoro S-nitrosothiols
Zhou, Yang
Tan, Jinyi
Dai, Yuping
Yu, Yanmin
Zhang, Qi
Meyerhoff, Mark E.
CHEMICAL COMMUNICATIONS, 2019, 55 (03) : 401 - 404
[16] Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells
Diers, Anne R.
Broniowska, Katarzyna A.
Darley-Usmar, Victor M.
Hogg, Neil
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2011, 301 (03): : H803 - H812
[17] Catalytic generation of nitric oxide from S-nitrosothiols using immobilized organoselenium species
Cha, Wansik
Meyerhoff, Mark E.
BIOMATERIALS, 2007, 28 (01) : 19 - 27
[18] Parsing the effects of nitric oxide, S-nitrosothiols, and peroxynitrite on inducible nitric oxide synthase-dependent cardiac myocyte apoptosis
Beckman, JS
CIRCULATION RESEARCH, 1999, 85 (09) : 870 - 871
[19] Dinitrosyl iron complexes and S-nitrosothiols are two possible forms for stabilization and transport of nitric oxide in biological systems
Vanin, AF
BIOCHEMISTRY-MOSCOW, 1998, 63 (07) : 782 - 793
[20] S-Nitrosothiols, Nitric Oxide and Proinflammatory Cytokines in Children with Inflammatory Bowel Disease
Kolesov, S. A.
Korkotashvili, L. V.
Yazykova, A. B.
Fedulova, E. N.
Tutina, O. A.
Tolkacheva, N. I.
CLINICAL LABORATORY, 2013, 59 (9-10) : 953 - 957

← 1 2 3 4 5 →