Introduction to poly(ADP-ribose) metabolism

被引：0

作者：

Diefenbach, J ^{[1
]}

Bürkle, A ^{[1
]}

机构：

[1] Univ Konstanz, Mol Toxicol Grp, D-78457 Constance, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2005年 / 62卷 / 7-8期

关键词：

PARP; poly(ADP-ribose); DNA damage; DNA repair; genomic instability; ageing;

D O I：

10.1007/s00018-004-4503-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poly(ADP-ribosyl)ation is a posttranslational modification of proteins in eukaryotic cells catalysed by a family of NAD(+) ADP-ribosyl transferases, the poly(ADP-ribose) polymerases (PARPs). PARP-encoding genes now constitute a superfamily of at least 18 members encoding proteins that share homology with the catalytic domain of the founding member, PARP-1 [1]. Poly(ADPribose) metabolism is of central importance in a wide variety of biological processes including maintenance of genomic stability [2-4], DNA repair [3, 5], transcriptional regulation [6, 7], centromere function [8, 9], modulation of telomere length [10-12], regulation of proteasomal protein degradation [13, 14], regulation of endosomal vesicle trafficking [15, 16] and apoptosis [17, 18]. The life cycle of poly(ADP-ribose) is discussed in the following section. In addition, an overview of the genes and proteins involved in poly(ADP-ribose) metabolism and their possible cellular function is provided.

引用

页码：721 / 730

页数：10

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