The essential functions of mitochondrial dynamics in immune cells

被引：67
作者：
Xie, Jia-Huan [1 ,2 ]
Li, Yi-Yuan [3 ]
Jin, Jin [1 ,2 ,4 ]
机构：
[1] Zhejiang Univ, MOE Lab Biosyst Homeostasis & Protect, Hangzhou 310058, Peoples R China
[2] Zhejiang Univ, Inst Life Sci, Hangzhou 310058, Peoples R China
[3] Southeast Univ, Jiangsu Prov High Tech Key Lab Biomed Res, Key Lab Dev Genes & Human Dis, Minist Educ,Inst Life Sci, Nanjing 210096, Peoples R China
[4] Zhejiang Univ, Coll Med, Sir Run Run Shaw Hosp, Hangzhou 310016, Peoples R China
来源：
CELLULAR & MOLECULAR IMMUNOLOGY | 2020年 / 17卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Mitochondrial dynamics; Metabolism; T cell; B cell; Innate immune cell; DEPENDENT PROTEIN-KINASE; CD4(+) T-CELLS; INFLAMMASOME ACTIVATION; NLRP3; INFLAMMASOME; DENDRITIC CELLS; B-CELLS; FISSION; MITOPHAGY; DRP1; DYSFUNCTION;
D O I：
10.1038/s41423-020-0480-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mitochondria are highly mobile organelles due to fission, fusion, transport, and mitophagy, and these processes are known as mitochondrial dynamics. Mitochondrial dynamics play an important role in energy production, cell division, cell differentiation, and cell death. In the past decade, numerous studies have revealed the importance of mitochondrial metabolism in immunity, and mitochondrial dynamics are essential for immune responses mediated by various cell types. In this review, we mainly discuss the role of mitochondrial dynamics in activation, differentiation, cytokine production, and the activity of related pathways in immune cells, particularly T cells, B cells, and other cells involved in the innate immune response.
引用
收藏
页码：712 / 721
页数：10
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