Palladium catalyzed C(sp3)-H acetoxylation of aliphatic primary amines to γ-amino alcohol derivatives

被引:73
作者
Chen, Kang [1 ,2 ]
Wang, Ding [1 ,2 ]
Li, Zhao-Wei [1 ,2 ]
Liu, Zheng [1 ,2 ]
Pan, Fei [1 ,2 ]
Zhang, Yun-Fei [1 ,2 ]
Shi, Zhang-Jie [1 ,2 ,3 ]
机构
[1] Peking Univ, BNLMS, Beijing 100871, Peoples R China
[2] Peking Univ, Coll Chem & Mol Engn, Key Lab Bioorgan Chem & Mlecular Engn, Minist Educ, Beijing 100871, Peoples R China
[3] Chinese Acad Sci, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
关键词
C-H BONDS; NITROGEN-HETEROCYCLES; DIRECTING GROUP; FUNCTIONALIZATION; ACTIVATION; ARYLATION; OXIDATION; LIGAND; PHARMACEUTICALS; OXYGENATION;
D O I
10.1039/c7qo00432j
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
It still remains a major challenge to apply free primary amino groups as the directing group for aliphatic C-H functionalization. In this article, we used the protonation strategy to control the binding ability of primary amines and realized free amino group directed inert aliphatic C-H acetoxylation in good chemo- and regio-selectivity. This methodology provided a straightforward approach from primary amines to gamma-amino alcohols.
引用
收藏
页码:2097 / 2101
页数:5
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