Is Predisposition to NAFLD and Obesity Communicable?

被引：8

作者：

Vijay-Kumar, Matam ^{[1
]}

Gewirtz, Andrew T. ^{[1
]}

机构：

[1] Georgia State Univ, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA

来源：

CELL METABOLISM | 2012年 / 15卷 / 04期

关键词：

D O I：

10.1016/j.cmet.2012.03.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A forthcoming article in Nature reveals that inflammasome deficiency disturbs gut microbiota and predisposes to diet-induced obesity and liver disease. The aberrant microbiota and its consequences could be transferred by cohousing mutant and wild-type mice, suggesting that some aspects of metabolic syndrome can be communicable (Henao-Mejia et al., 2012).

引用

页码：419 / 420

页数：2

共 5 条

[1] RETRACTED: Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice (Retracted Article) [J].

Caricilli, Andrea M. ;

Picardi, Paty K. ;

de Abreu, Lelia L. ;

Ueno, Mirian ;

Prada, Patricia O. ;

Ropelle, Eduardo R. ;

Hirabara, Sandro Massao ;

Castoldi, Angela ;

Vieira, Pedro ;

Camara, Niels O. S. ;

Curi, Rui ;

Carvalheira, Jose B. ;

Saad, Mario J. A. .

PLOS BIOLOGY, 2011, 9 (12)

[2] Inflammatory Mechanisms in Obesity [J].

Gregor, Margaret F. ;

Hotamisligil, Goekhan S. .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29, 2011, 29 :415-445

[3] Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity [J].

Henao-Mejia, Jorge ;

Elinav, Eran ;

Jin, Chengcheng ;

Hao, Liming ;

Mehal, Wajahat Z. ;

Strowig, Till ;

Thaiss, Christoph A. ;

Kau, Andrew L. ;

Eisenbarth, Stephanie C. ;

Jurczak, Michael J. ;

Camporez, Joao-Paulo ;

Shulman, Gerald I. ;

Gordon, Jeffrey I. ;

Hoffman, Hal M. ;

Flavell, Richard A. .

NATURE, 2012, 482 (7384) :179-U67

[4] Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance [J].

Netea, MG ;

Joosten, LAB ;

Lewis, E ;

Jensen, DR ;

Voshol, PJ ;

Kullberg, BJ ;

Tack, CJ ;

van Krieken, H ;

Kim, SH ;

Stalenhoef, AF ;

Van de Loo, FA ;

Verschueren, I ;

Pulawa, L ;

Akira, S ;

Eckel, RH ;

Dinarello, CA ;

Van den Berg, W ;

Van der Meer, JWM .

NATURE MEDICINE, 2006, 12 (06) :650-656

[5] Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5 [J].

Vijay-Kumar, Matam ;

Aitken, Jesse D. ;

Carvalho, Frederic A. ;

Cullender, Tyler C. ;

Mwangi, Simon ;

Srinivasan, Shanthi ;

Sitaraman, Shanthi V. ;

Knight, Rob ;

Ley, Ruth E. ;

Gewirtz, Andrew T. .

SCIENCE, 2010, 328 (5975) :228-231

← 1 →