Single-arc volumetric-modulated arc therapy can provide dose distributions equivalent to fixed-beam intensity-modulated radiation therapy for prostatic irradiation with seminal vesicle and/or lymph node involvement

被引:20
作者
Fontenot, J. D. [1 ,2 ,3 ]
King, M. L. [1 ,2 ,3 ]
Johnson, S. A. [1 ,2 ,3 ]
Wood, C. G. [1 ,2 ,3 ]
Price, M. J. [1 ,2 ,3 ]
Lo, K. K. [1 ,2 ,3 ]
机构
[1] Mary Bird Perkins Canc Ctr, Baton Rouge, LA 70809 USA
[2] Louisiana State Univ, Dept Phys & Astron, Baton Rouge, LA 70803 USA
[3] Agr & Mech Coll, Baton Rouge, LA USA
关键词
CANCER; RADIOTHERAPY; IMRT;
D O I
10.1259/bjr/94843998
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objectives: Volumetric-modulated arc therapy (VMAT) is becoming an increasingly utilised modality for treating a variety of anatomical sites. However, the efficacy of single-arc VMAT to treat prostate cancer suspicious for extraprostatic extension was heretofore unknown. In this work, we report our institutional experience with single-arc VMAT and fixed-beam intensity-modulated radiation therapy (IMRT) for prostate cancer patients treated for seminal vesicle and/or lymph node involvement. Methods: Single-arc VMAT and 7- or 9-field IMRT treatment plans were compared for 10 prostate cancer patients treated for seminal vesicle involvement and/or lymph node involvement. All treatment plans were constructed using the Philips Pinnacle treatment planning system (v.9.0, Fitchburg, WI) and delivered on an Elekta Infinity radiotherapy accelerator (Crawley, UK). Resulting plans were compared using metrics that characterised dosimetry and delivery efficiency. Results: No statistically significant differences in target coverage, target homogeneity or normal tissue doses were noted between the plans (p > 0.05). For prostate patients treated for seminal vesicle involvement, VMAT plans were delivered in 1.4 +/- 0.1 min (vs 9.5 +/- 2.4 min for fixed-beam IMRT) (p < 0.01) and required approximately 20% fewer monitor units (p=0.01). For prostate patients treated for lymph node involvement, VMAT plans were delivered in 1.4 +/- 0.1 min (vs 11.7 +/- 1.3 min for fixed-beam IMRT) (p < 0.01) and required approximately 45% fewer monitor units (p < 0.01). Conclusion: Single-arc VMAT plans were dosimetrically equivalent to fixed-beam IMRT plans with significantly improved delivery efficiency.
引用
收藏
页码:231 / 236
页数:6
相关论文
共 16 条
  • [1] COMMISSIONING OF VOLUMETRIC MODULATED ARC THERAPY (VMAT)
    Bedford, James L.
    Warrington, Alan P.
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2009, 73 (02): : 537 - 545
  • [2] The number of beams in IMRT-theoretical investigations and implications for single-arc IMRT
    Bortfeld, Thomas
    [J]. PHYSICS IN MEDICINE AND BIOLOGY, 2010, 55 (01) : 83 - 97
  • [3] Single-Arc IMRT?
    Bortfeld, Thomas
    Webb, Steve
    [J]. PHYSICS IN MEDICINE AND BIOLOGY, 2009, 54 (01) : N9 - N20
  • [4] Intensity-modulated radiotherapy: Current status and issues of interest
    Boyer, AL
    Butler, EB
    DiPetrillo, TA
    Engler, MJ
    Fraass, B
    Grant, W
    Ling, CC
    Low, DA
    Mackie, TR
    Mohan, R
    Purdy, JA
    Roach, M
    Rosenman, JG
    Verhey, LJ
    Wong, JW
    Cumberlin, RL
    Stone, H
    Palta, JR
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 51 (04): : 880 - 914
  • [5] Development and evaluation of an efficient approach to volumetric arc therapy planning
    Bzdusek, Karl
    Friberger, Henrik
    Eriksson, Kjell
    Hardemark, Bjorn
    Robinson, David
    Kaus, Michael
    [J]. MEDICAL PHYSICS, 2009, 36 (06) : 2328 - 2339
  • [6] Is a single arc sufficient in volumetric-modulated arc therapy (VMAT) for complex-shaped target volumes?
    Guckenberger, Matthias
    Richter, Anne
    Krieger, Thomas
    Wilbert, Juergen
    Baier, Kurt
    Flentje, Michael
    [J]. RADIOTHERAPY AND ONCOLOGY, 2009, 93 (02) : 259 - 265
  • [7] RapidArc volumetric modulated therapy planning for prostate cancer patients
    Kjaer-Kristoffersen, Flemming
    Ohlhues, Lars
    Medin, Joakim
    Korreman, Stine
    [J]. ACTA ONCOLOGICA, 2009, 48 (02) : 227 - 232
  • [8] Preliminary report of toxicity following 3D radiation therapy for prostate cancer on 3DOG/RTOG 9406
    Michalski, JM
    Purdy, JA
    Winter, K
    Roach, M
    Vijayakumar, S
    Sandler, HM
    Markoe, AM
    Ritter, MA
    Russell, KJ
    Sailer, S
    Harms, WB
    Perez, CA
    Wilder, RB
    Hanks, GE
    Cox, JD
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2000, 46 (02): : 391 - 402
  • [9] Volumetric modulated arc therapy: IMRT in a single gantry arc
    Otto, Karl
    [J]. MEDICAL PHYSICS, 2008, 35 (01) : 310 - 317
  • [10] Letter to the Editor on 'Single-Arc IMRT?'
    Otto, Karl
    [J]. PHYSICS IN MEDICINE AND BIOLOGY, 2009, 54 (08) : L37 - L41