piRNAs: biogenesis and their potential roles in cancer

被引：105

作者：

Guo, Binghong ^{[1
,2
]}

Li, Dongpei ^{[3
]}

Du, Likun ^{[4
]}

Zhu, Xiao ^{[1
,2
]}

机构：

[1] Guangdong Med Univ, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Peoples R China

[2] Guangdong Med Univ, Marine Biomed Res Inst, Southern Sci & Engn Guangdong Lab Zhanjiang, Zhanjiang 524023, Peoples R China

[3] Augusta Univ, Med Coll Georgia, Augusta, GA 30912 USA

[4] Heilongjiang Univ Tradit Chinese Med, Affiliated Hosp 1, Harbin 150040, Peoples R China

来源：

CANCER AND METASTASIS REVIEWS | 2020年 / 39卷 / 02期

基金：

中国国家自然科学基金;

关键词：

piRNAs; PIWI; Cancer metastasis; Biogenesis; piRISC; PIWI-INTERACTING RNA; NONCODING RNA; UP-REGULATION; EXPRESSION; PIR-823; IDENTIFICATION; TUMORIGENESIS; CARCINOMA; INVASION; TARGET;

D O I：

10.1007/s10555-020-09863-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With the length of about 26-31 nt, PIWI-interacting RNA (piRNA) is a small non-coding RNA (ncRNA) that interacts with PIWI proteins to form the piRNA silencing complex (piRISC). PIWI is a subfamily of Argonaute, and piRNA must bind to PIWI to exert its regulatory role. Current studies indicated that piRNA and PIWI are significantly abnormally expressed in gastric, breast, kidney, colon, and lung cancers, and are involved in the initiation, progression, and metastasis of cancers, which may be the potential diagnostic tools, prognostic markers, and therapeutic targets for cancers. By reviewing piRNA recent studies, this research summarized the mechanism of piRNA generation and the functions of piRNA/PIWI in gastric, breast, kidney, colon, and lung cancers, providing a reference value for further piRNA research.

引用

页码：567 / 575

页数：9

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