Synthesis of Pyrido[2,3-b]indole Derivatives via Rhodium-Catalyzed Cyclization of Indoles and 1-Sulfonyl-1,2,3-triazoles

被引：15

作者：

Duan, Shengguo ^{[1
]}

An, Yuehui ^{[1
]}

Xue, Bing ^{[1
]}

Chen, Yidian ^{[1
]}

Zhang, Wan ^{[1
]}

Xu, Ze-Feng ^{[1
]}

Li, Chuan-Ying ^{[1
]}

机构：

[1] Zhejiang Sci Tech Univ, Dept Chem, Hangzhou 310018, Zhejiang, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2020年 / 362卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Pyrido[2; 3-b]indole; 4+2] Annulation; Aza-[4 C] synthon; Carbenes; 1; 2; 3-Triazole; METAL-FREE SYNTHESIS; COMMUNESIN F; DENITROGENATIVE TRANSANNULATION; ASYMMETRIC-SYNTHESIS; TANDEM REACTION; PYRROLOINDOLINES; ACCESS; SCAFFOLDS; N-SULFONYL-1,2,3-TRIAZOLES; (-)-CHAETOMININE;

D O I：

10.1002/adsc.201901599

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Acyloxy-substituted alpha,beta-unsaturated imines generated in situ from triazoles can act as aza-[4 C] synthons and be trapped by indoles in a stepwise [4 + 2] cycloaddition reaction, thus providing rapid access to valuable pyrido[2,3-b]indoles in high yields. Attractive features of this reaction system include operational simplicity, readily available substrates, construction of sterically demanding quaternary centers, and convenient derivatization using triflate.

引用

页码：1831 / 1835

页数：5

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