Pre-existing antiacetylcholine receptor autoantibodies and B cell lymphopaenia are associated with the development of myositis in patients with thymoma treated with avelumab, an immune checkpoint inhibitor targeting programmed death-ligand 1

被引：97

作者：

Mammen, Andrew L. ^{[1
]}

Rajan, Arun ^{[2
]}

Pak, Katherine ^{[1
]}

Lehky, Tanya ^{[3
]}

Casciola-Rosen, Livia ^{[4
]}

Donahue, Renee N. ^{[5
]}

Lepone, Lauren M. ^{[5
]}

Zekeridou, Anastasia ^{[6
]}

Pittock, Sean J. ^{[6
]}

Hassan, Raffit ^{[2
]}

Schlom, Jeffrey ^{[5
]}

Gulley, James L. ^{[5
,7
]}

机构：

[1] NIAMSD, Lab Muscle Stem Cells & Gene Regulat, NIH, Bethesda, MD 20892 USA

[2] NCI, Thorac & Gastrointestinal Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[3] NINDS, Electromyog Sect, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[4] Johns Hopkins Univ Hosp, Dept Med, Div Rheumatol, Baltimore, MD 21287 USA

[5] NCI, Lab Tumor Immunol & Biol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[6] Mayo Clin, Neuroimmunol Lab, Rochester, MN USA

[7] NCI, Genitourinary Malignancies Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2019年 / 78卷 / 01期

基金：

美国国家卫生研究院;

关键词：

JAVELIN SOLID TUMOR;

D O I：

10.1136/annrheumdis-2018-213777

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：150 / 152

页数：3

共 6 条

[1] Thymoma associated with autoimmune diseases: 85 cases and literature review [J].

Bernard, C. ;

Frih, H. ;

Pasquet, F. ;

Kerever, S. ;

Jamilloux, Y. ;

Tronc, F. ;

Guibert, B. ;

Isaac, S. ;

Devouassoux, M. ;

Chalabreysse, L. ;

Broussolle, C. ;

Petiot, P. ;

Girard, N. ;

Seve, P. .

AUTOIMMUNITY REVIEWS, 2016, 15 (01) :82-92

[2] Coexisting myasthenia gravis, myositis, and polyneuropathy induced by ipilimumab and nivolumab in a patient with non-small-cell lung cancer A case report and literature review [J].

Chen, Jia-Hung ;

Lee, Kang-Yun ;

Hu, Chaur-Jong ;

Chung, Chen-Chih .

MEDICINE, 2017, 96 (50)

[3] Early B cell changes predict autoimmunity following combination immune checkpoint blockade [J].

Das, Rituparna ;

Bar, Noffar ;

Ferreira, Michelle ;

Newman, Aaron M. ;

Zhang, Lin ;

Bailur, Jithendra Kini ;

Bacchiocchi, Antonella ;

Kluger, Harriet ;

Wei, Wei ;

Halaban, Ruth ;

Sznol, Mario ;

Dhodapkar, Madhav V. ;

Dhodapkar, Kavita M. .

JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (02) :715-720

[4] Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial [J].

Heery, Christopher R. ;

O'Sullivan-Coyne, Geraldine ;

Madan, Ravi A. ;

Cordes, Lisa ;

Rajan, Arun ;

Rauckhorst, Myrna ;

Lamping, Elizabeth ;

Oyelakin, Israel ;

Marte, Jennifer L. ;

Lepone, Lauren M. ;

Donahue, Renee N. ;

Grenga, Italia ;

Cuillerot, Jean-Marie ;

Neuteboom, Berend ;

von Heydebreck, Anja ;

Chin, Kevin ;

Schlom, Jeffrey ;

Gulley, James L. .

LANCET ONCOLOGY, 2017, 18 (05) :587-598

[5] Safety Profile of Avelumab in Patients With Advanced Solid Tumors: A Pooled Analysis of Data From the Phase 1 JAVELIN Solid Tumor and Phase 2 JAVELIN Merkel 200 Clinical Trials [J].

Kelly, Karen ;

Infante, Jeffrey R. ;

Taylor, Matthew H. ;

Patel, Manish R. ;

Wong, Deborah J. ;

Iannotti, Nicholas ;

Mehnert, Janice M. ;

Loos, Anja H. ;

Koch, Helga ;

Speit, Isabell ;

Gulley, James L. .

CANCER, 2018, 124 (09) :2010-2017

[6] B-cell lymphopenia and hypogammaglobulinemia in thymoma patients [J].

Montella, L ;

Masci, AM ;

Merkabaoui, G ;

Perna, F ;

Vitiello, L ;

Racioppi, L ;

Palmieri, G .

ANNALS OF HEMATOLOGY, 2003, 82 (06) :343-347

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