Myocardial ischaemia reperfusion injury and cardioprotection in the presence of sensory neuropathy: Therapeutic options

被引：19

作者：

Bencsik, Peter ^{[1
,2
]}

Gomori, Kamilla ^{[1
,2
]}

Szabados, Tamara ^{[1
,2
]}

Santha, Peter ^{[3
]}

Helyes, Zsuzsanna ^{[4
,5
]}

Jancso, Gabor ^{[3
]}

Ferdinandy, Peter ^{[2
,6
]}

Gorbe, Aniko ^{[1
,2
,6
]}

机构：

[1] Univ Szeged, Dept Pharmacol & Pharmacotherapy, Cardiovasc Res Grp, Fac Med, Dom Ter 12, H-6720 Szeged, Hungary

[2] Pharmahungary Grp, Szeged, Hungary

[3] Univ Szeged, Dept Physiol, Fac Med, Szeged, Hungary

[4] Univ Pecs, Med Sch, Dept Pharmacol & Pharmacotherapy, Pecs, Hungary

[5] Univ Pecs, Mol Pharmacol Res Grp, Ctr Neurosci, Janos Szentagothai Res Ctr, Pecs, Hungary

[6] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, Budapest, Hungary

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2020年 / 177卷 / 23期

关键词：

GENE-RELATED PEPTIDE; CARDIOVASCULAR AUTONOMIC NEUROPATHY; IMPAIRS POSTISCHEMIC RECOVERY; MOUSE MODEL; HEART-FAILURE; ISCHEMIA/REPERFUSION INJURY; SELECTIVE DEGENERATION; PERIPHERAL NEUROPATHY; CARDIAC INNERVATION; CAPSAICIN RECEPTOR;

D O I：

10.1111/bph.15021

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

During the last decades, mortality from acute myocardial infarction has been dramatically reduced. However, the incidence of post-infarction heart failure is still increasing. Cardioprotection by ischaemic conditioning had been discovered more than three decades ago. Its clinical translation, however, is still an unmet need. This is mainly due to the disrupted cardioprotective signalling pathways in the presence of different cardiovascular risk factors, co-morbidities and the medication being taken. Sensory neuropathy is one of the co-morbidities that has been shown to interfere with cardioprotection. In the present review, we summarize the diverse aetiology of sensory neuropathies and the mechanisms by which these neuropathies may interfere with ischaemic heart disease and cardioprotective signalling. Finally, we suggest future therapeutic options targeting both ischaemic heart and sensory neuropathy simultaneously.

引用

页码：5336 / 5356

页数：21

共 163 条

[21] Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjogren's syndrome [J].