Neuropathological findings in West Nile virus encephalitis: A case report

被引：36
作者：
Agamanolis, DP
Leslie, MJ
Caveny, EA
Guarner, J
Shieh, WJ
Zaki, SR
机构：
[1] Childrens Hosp, Med Ctr, Dept Pathol, Coll Med, Akron, OH 44308 USA
[2] Northeastern Ohio Univ Coll Med & Pharm, Coll Med, Dept Pathol, Med Ctr, Akron, OH USA
[3] Akron Gen Med Ctr, Dept Neurol, Akron, OH USA
[4] Akron Gen Med Ctr, Dept Pathol, Akron, OH USA
[5] Ctr Dis Control & Prevent, Atlanta, GA USA
来源：
ANNALS OF NEUROLOGY | 2003年 / 54卷 / 04期
关键词：
D O I：
10.1002/ana.10731
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A 67-year-old woman had fever, myalgias, progressive weakness, and respiratory insufficiency. In 9 days, flaccid areflexic quadriparesis and bulbar palsy developed. She died 26 days after the onset of her illness. Serum and cerebrospinal fluid serology were positive for West Nile virus. Neuropathological study showed changes consistent with a viral encephalomyelitis, similar to poliomyelitis. The brainstem showed neuronal loss and multiple foci of necrosis. The spinal cord showed severe loss of anterior and posterior horn neurons. Immunohistochemistry identified West Nile virus antigens in the brainstem and spinal cord. Paralysis, in West Nile virus encephalitis, is caused by destruction of motor neurons.
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页码：547 / 551
页数：5
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