Developing Medicines That Mimic the Natural Successes of the Human Genome Lessons From NPC1L1, HMGCR, PCSK9, APOC3, and CETP*

被引：33

作者：

Kathiresan, Sekar ^{[1
,2
,3
,4
]}

机构：

[1] MGH, Ctr Human Genet Res, Boston, MA 02114 USA

[2] MGH, Cardiovasc Res Ctr, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[4] Broad Inst MIT & Harvard, Cambridge, MA USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2015年 / 65卷 / 15期

关键词：

cholesterol; coronary disease; genetic association studies; genetics; human genome; medical; triglycerides; DENSITY-LIPOPROTEIN CHOLESTEROL; OF-FUNCTION MUTATIONS; RISK; LOCI; EZETIMIBE; LDL; TRIGLYCERIDES; DEFICIENCY; PROTECTION; DARAPLADIB;

D O I：

10.1016/j.jacc.2015.02.049

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：1562 / 1566

页数：5

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