Lignans from Saururus chinensis inhibiting the transcription factor NF-κB

被引：87

作者：

Hwang, BY ^{[1
]}

Lee, JH ^{[1
]}

Nam, JB ^{[1
]}

Hong, YS ^{[1
]}

Lee, JJ ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Anticanc Res Lab, Taejon 305600, South Korea

来源：

PHYTOCHEMISTRY | 2003年 / 64卷 / 03期

关键词：

Saururus chinensis; Saururaceae; sesquineolignan; lignan; saucerneol D; saucerneol E; nuclear factor kappa B;

D O I：

10.1016/S0031-9422(03)00391-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sesquineolignans, saucerneol D and saucerneol E were isolated from the roots of Saururus chinensis together with four known lignans, manassantin A, manassantin B, (-)-saucerneol methyl ether, and (+)-saucernetin. Structure elucidation was based on the analysis of spectroscopic data and anti-inflammatory activity was studied using HeLa cells transfected with NF-kappaB reporter construct. All compounds except for (+)-saucernetin inhibited NF-kappaB dependent reporter gene expression with IC50 values of 2.5-16.9 muM. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：765 / 771

页数：7

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