Mesenchymal stem cells and hypoxia: Where are we?

被引：109

作者：

Buravkova, L. B. ^{[1
,2
]}

Andreeva, E. R. ^{[1
]}

Gogvadze, V. ^{[2
,3
]}

Zhivotovsky, B. ^{[2
,3
]}

机构：

[1] Russian Acad Sci, Inst Biomed Problems, Moscow, Russia

[2] Moscow MV Lomonosov State Univ, Fac Basic Med, Moscow 119991, Russia

[3] Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden

来源：

MITOCHONDRION | 2014年 / 19卷

基金：

俄罗斯科学基金会; 瑞典研究理事会;

关键词：

Mesenchymal stem cells; Hypoxia; Mitochondria; Cell death; DEPRIVATION-INDUCED APOPTOSIS; REDUCED OXYGEN-TENSION; BONE-MARROW; STROMAL CELLS; OSTEOGENIC DIFFERENTIATION; IN-VITRO; MITOCHONDRIAL BIOGENESIS; CELLULAR ADAPTATION; ANTIOXIDANT ENZYMES; PROMOTES AUTOPHAGY;

D O I：

10.1016/j.mito.2014.07.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Multipotent mesenchymal stromal cells (MSCs) are involved in the organization and maintenance of tissue integrity. MSCs have also attracted attention as a promising tool for cell therapy and regenerative medicine. However, their usage is limited due to cell impairment induced by an extremely harsh microenvironment during transplantation ex vivo. The microenvironment of MSCs in tissue depots is characterized by rather low oxygen consumption, demonstrating that MSCs might be quite resistant to oxygen limitation. However, accumulated data revealed that the response of MSCs to hypoxic conditions is rather controversial, demonstrating both damaging and ameliorating effects. Here, we make an attempt to summarize recent knowledge on the survival of MSCs under low oxygen conditions of varying duration and severity and to elucidate the mechanisms of MSC resistance/sensitivity to hypoxic impact. (C) 2014 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：105 / 112

页数：8

共 89 条

[11] Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells [J].

Chacko, Simi M. ;

Ahmed, Shabnam ;

Selvendiran, Karuppaiyah ;

Kuppusamy, M. Lakshmi ;

Khan, Mahmood ;

Kuppusamy, Periannan .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2010, 299 (06) :C1562-C1570

[12] Mesenchymal Stem Cells Pretreated with Delivered Hph-1-Hsp70 Protein Are Protected from Hypoxia-Mediated Cell Death and Rescue Heart Functions from Myocardial Injury [J].

Chang, Woochul ;

Song, Byeong-Wook ;

Lim, Soyeon ;

Song, Heesang ;

Shim, Chi Young ;

Cha, Min-Ji ;

Ahn, Dong Hyuck ;

Jung, Young-Gook ;

Lee, Dong-Ho ;

Chung, Ji Hyung ;

Choi, Ki-Doo ;

Lee, Seung-Kyou ;

Chung, Namsik ;

Lee, Sang-Kyou ;

Jang, Yangsoo ;

Hwang, Ki-Chul .

STEM CELLS, 2009, 27 (09) :2283-2292

[13] Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells [J].

Chen, Chien-Tsun ;

Shih, Yu-Ru V. ;

Kuo, Tom K. ;

Lee, Oscar K. ;

Wei, Yau-Huei .

STEM CELLS, 2008, 26 (04) :960-968

[14] Mitochondrial bioenergetic function and metabolic plasticity in stem cell differentiation and cellular reprogramming [J].

Chen, Chien-Tsun ;

Hsu, Shu-Han ;

Wei, Yau-Huei .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2012, 1820 (05) :571-576

[15] Lysophosphatidic acid protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis [J].

Chen, Jinghai ;

Baydoun, Anwar R. ;

Xu, Ruixia ;

Deng, Linzi ;

Liu, Xuebin ;

Zhu, Weiquan ;

Shi, Linhui ;

Cong, Xiangfeng ;

Hu, Shengshou ;

Chen, Xi .

STEM CELLS, 2008, 26 (01) :135-145

[16] Dynamic changes in mitochondrial biogenesis and antioxidant enzymes during the spontaneous differentiation of human embryonic stem cells [J].

Cho, Young Min ;

Kwon, Sujin ;

Pak, Youngmi Kim ;

Seol, Hye Won ;

Choi, Young Min ;

Park, Do Joon ;

Park, Kyong Soo ;

Lee, Hong Kyu .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 348 (04) :1472-1478

[17] Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells [J].

Chung S. ;

Dzeja P.P. ;

Faustino R.S. ;

Perez-Terzic C. ;

Behfar A. ;

Terzic A. .

Nature Clinical Practice Cardiovascular Medicine, 2007, 4 (Suppl 1) :S60-S67

[18] Human mesenchymal stem cells stimulated by TNF-α, LPS, or hypoxia produce growth factors by an NFκB- but not JNK-dependent mechanism [J].

Crisostomo, Paul R. ;

Wang, Yue ;

Markel, Troy A. ;

Wang, Meijing ;

Lahm, Tim ;

Meldrum, Daniel R. .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2008, 294 (03) :C675-C682

[19] Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells [J].

D'Ippolito, Gianluca ;

Diabira, Sylma ;

Howard, Guy A. ;

Roos, Bernard A. ;

Schiller, Paul C. .

BONE, 2006, 39 (03) :513-522

[20] HIF-1α induced-VEGF overexpression in bone marrow stem cells protects cardiomyocytes against ischemia [J].

Dai, Ying ;

Xu, Meifeng ;

Wang, Yigang ;

Pasha, Zeeshan ;

Li, Tingyu ;

Ashraf, Muhammad .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2007, 42 (06) :1036-1044

← 1 2 3 4 5 6 7 8 9 →