Diagnostic biomarkers for Parkinson's disease at a glance: where are we?

被引：61
作者：
Cova, Ilaria [1 ]
Priori, Alberto [2 ,3 ]
机构：
[1] L Sacco Univ Hosp, Neurol Unit, Milan, Italy
[2] Univ Milan, Aldo Ravelli Res Ctr Neurotechnol & Expt Brain Th, Dept Hlth Sci, Milan, Italy
[3] ASST Santi Paolo & Carlo, Milan, Italy
来源：
JOURNAL OF NEURAL TRANSMISSION | 2018年 / 125卷 / 10期
关键词：
Parkinson's disease; Diagnosis; Biomarkers; EXCESSIVE DAYTIME SLEEPINESS; PLASMA ALPHA-SYNUCLEIN; MDS RESEARCH CRITERIA; SUBSTANTIA-NIGRA; REM-SLEEP; OLFACTORY FUNCTION; NEURODEGENERATIVE DISEASE; CLINICAL PROGRESSION; CEREBROSPINAL-FLUID; APOLIPOPROTEIN A1;
D O I：
10.1007/s00702-018-1910-4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Parkinson's disease (PD) is a neurodegenerative disorder whose aetiology remains unclear: degeneration involves several neurotransmission systems, resulting in a heterogeneous disease characterized by motor and non-motor symptoms. PD causes progressive disability that responds only to symptomatic therapies. Future advances include neuroprotective strategies for use in at-risk populations before the clinical onset of disease, hence the continuing need to identify reliable biomarkers that can facilitate the clinical diagnosis of PD. In this evaluative review, we summarize information on potential diagnostic biomarkers for use in the clinical and preclinical stages of PD.
引用
收藏
页码：1417 / 1432
页数：16
相关论文
共 142 条
[71]   Plasma α-synuclein is decreased in subjects with Parkinson's disease [J].
Li, Qiao-Xin ;
Mok, Su San ;
Laughton, Katrina M. ;
McLean, Catriona A. ;
Cappai, Roberto ;
Masters, Colin L. ;
Culvenor, Janetta G. ;
Horne, Malcolm K. .
EXPERIMENTAL NEUROLOGY, 2007, 204 (02) :583-588
[72]   Relation of risk factors and putative premotor markers for Parkinson's disease [J].
Liepelt-Scarfone, I. ;
Behnke, S. ;
Godau, J. ;
Schweitzer, K. J. ;
Wolf, B. ;
Gaenslen, A. ;
Berg, D. .
JOURNAL OF NEURAL TRANSMISSION, 2011, 118 (04) :579-585
[73]   DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease [J].
Lin, Xiangmin ;
Cook, Travis J. ;
Zabetian, Cyrus P. ;
Leverenz, James B. ;
Peskind, Elaine R. ;
Hu, Shu-Ching ;
Cain, Kevin C. ;
Pan, Catherine ;
Edgar, John Scott ;
Goodlett, David R. ;
Racette, Brad A. ;
Checkoway, Harvey ;
Montine, Thomas J. ;
Shi, Min ;
Zhang, Jing .
SCIENTIFIC REPORTS, 2012, 2
[74]   The Treatment of Sleep Disorders in Parkinson's Disease: From Research to Clinical Practice [J].
Loddo, Giuseppe ;
Calandra-Buonaura, Giovanna ;
Sambati, Luisa ;
Giannini, Giulia ;
Cecere, Annagrazia ;
Cortelli, Pietro ;
Provini, Federica .
FRONTIERS IN NEUROLOGY, 2017, 8
[75]   Elevated excretion of biopyrrin as a new marker for idiopathic Parkinson's disease [J].
Luan, Hemi ;
Liu, Liang-Feng ;
Tang, Zhi ;
Mok, Vincent C. T. ;
Li, Min ;
Cai, Zongwei .
PARKINSONISM & RELATED DISORDERS, 2015, 21 (11) :1371-1372
[76]  
Lucio CG, 2013, NUCL MED REV, V16, P35, DOI 10.5603/NMR.2013.0007
[77]   Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directions [J].
Magdalinou, Nadia ;
Lees, Andrew J. ;
Zetterberg, Henrik .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2014, 85 (10) :1065-1075
[78]   Meta-Analysis of Dorsolateral Nigral Hyperintensity on Magnetic Resonance Imaging as a Marker for Parkinson's Disease [J].
Mahlknecht, Philipp ;
Krismer, Florian ;
Poewe, Werner ;
Seppi, Klaus .
MOVEMENT DISORDERS, 2017, 32 (04) :619-623
[79]   Prodromal Parkinson's disease as defined per MDS research criteria in the general elderly community [J].
Mahlknecht, Philipp ;
Gasperi, Arno ;
Willeit, Peter ;
Kiechl, Stefan ;
Stockner, Heike ;
Willeit, Johann ;
Rungger, Gregorio ;
Sawires, Martin ;
Nocker, Michael ;
Rastner, Verena ;
Mair, Katherina J. ;
Hotter, Anna ;
Poewe, Werner ;
Seppi, Klaus .
MOVEMENT DISORDERS, 2016, 31 (09) :1405-1408
[80]   Predicting motor decline and disability in Parkinson disease - A systematic review [J].
Marras, C ;
Rochon, P ;
Lang, AE .
ARCHIVES OF NEUROLOGY, 2002, 59 (11) :1724-1728
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