Diagnostic biomarkers for Parkinson's disease at a glance: where are we?

被引：61
作者：
Cova, Ilaria [1 ]
Priori, Alberto [2 ,3 ]
机构：
[1] L Sacco Univ Hosp, Neurol Unit, Milan, Italy
[2] Univ Milan, Aldo Ravelli Res Ctr Neurotechnol & Expt Brain Th, Dept Hlth Sci, Milan, Italy
[3] ASST Santi Paolo & Carlo, Milan, Italy
来源：
JOURNAL OF NEURAL TRANSMISSION | 2018年 / 125卷 / 10期
关键词：
Parkinson's disease; Diagnosis; Biomarkers; EXCESSIVE DAYTIME SLEEPINESS; PLASMA ALPHA-SYNUCLEIN; MDS RESEARCH CRITERIA; SUBSTANTIA-NIGRA; REM-SLEEP; OLFACTORY FUNCTION; NEURODEGENERATIVE DISEASE; CLINICAL PROGRESSION; CEREBROSPINAL-FLUID; APOLIPOPROTEIN A1;
D O I：
10.1007/s00702-018-1910-4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Parkinson's disease (PD) is a neurodegenerative disorder whose aetiology remains unclear: degeneration involves several neurotransmission systems, resulting in a heterogeneous disease characterized by motor and non-motor symptoms. PD causes progressive disability that responds only to symptomatic therapies. Future advances include neuroprotective strategies for use in at-risk populations before the clinical onset of disease, hence the continuing need to identify reliable biomarkers that can facilitate the clinical diagnosis of PD. In this evaluative review, we summarize information on potential diagnostic biomarkers for use in the clinical and preclinical stages of PD.
引用
收藏
页码：1417 / 1432
页数：16
相关论文
共 142 条
[1]   Excessive daytime sleepiness and subsequent development of Parkinson disease [J].
Abbott, RD ;
Ross, GW ;
White, LR ;
Tanner, CM ;
Masaki, KH ;
Nelson, JS ;
Curb, JD ;
Petrovitch, H .
NEUROLOGY, 2005, 65 (09) :1442-1446
[2]   Frequency of bowel movements and the future risk of Parkinson's disease [J].
Abbott, RD ;
Petrovitch, H ;
White, LR ;
Masaki, KH ;
Tanner, CM ;
Curb, JD ;
Grandinetti, A ;
Blanchette, PL ;
Popper, JS ;
Ross, GW .
NEUROLOGY, 2001, 57 (03) :456-462
[3]   Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA [J].
Abd-Elhadi, Suaad ;
Basora, Misericordia ;
Vilas, Dolores ;
Tolosa, Eduardo ;
Sharon, Ronit .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2016, 408 (27) :7669-7677
[4]   Sleep Disturbances in the Prodromal Stage of Parkinson Disease [J].
Al-Qassabi, Ahmed ;
Fereshtehnejad, Seyed-Mohammad ;
Postuma, Ronald B. .
CURRENT TREATMENT OPTIONS IN NEUROLOGY, 2017, 19 (06)
[5]  
[Anonymous], 2016, ACTA NEUROL SCAND
[6]   Oculo-Visual Dysfunction in Parkinson's Disease [J].
Armstrong, R. A. .
JOURNAL OF PARKINSONS DISEASE, 2015, 5 (04) :715-726
[7]   Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework [J].
Atkinson, AJ ;
Colburn, WA ;
DeGruttola, VG ;
DeMets, DL ;
Downing, GJ ;
Hoth, DF ;
Oates, JA ;
Peck, CC ;
Schooley, RT ;
Spilker, BA ;
Woodcock, J ;
Zeger, SL .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :89-95
[8]   TRANSCRANIAL SONOGRAPHY IN THE PREMOTOR DIAGNOSIS OF PARKINSON'S DISEASE [J].
Behnke, Stefanie ;
Schroeder, Ute ;
Berg, Daniela .
TRANSCRANIAL SONOGRAPHY IN MOVEMENT DISORDERS, 2010, 90 :93-106
[9]   MDS research criteria for prodromal Parkinson's disease [J].
Berg, Daniela ;
Postuma, Ronald B. ;
Adler, Charles H. ;
Bloem, Bastiaan R. ;
Chan, Piu ;
Dubois, Bruno ;
Gasser, Thomas ;
Goetz, Christopher G. ;
Halliday, Glenda ;
Joseph, Lawrence ;
Lang, Anthony E. ;
Liepelt-Scarfone, Inga ;
Litvan, Irene ;
Marek, Kenneth ;
Obeso, Jose ;
Oertel, Wolfgang ;
Olanow, C. Warren ;
Poewe, Werner ;
Stern, Matthew ;
Deuschl, Guenther .
MOVEMENT DISORDERS, 2015, 30 (12) :1600-1609
[10]   Changing the research criteria for the diagnosis of Parkinson's disease: obstacles and opportunities [J].
Berg, Daniela ;
Lang, Anthony E. ;
Postuma, Ronald B. ;
Maetzler, Walter ;
Deuschl, Guenther ;
Gasser, Thomas ;
Siderowf, Andrew ;
Schapira, Anthony H. ;
Oertel, Wolfgang ;
Obeso, Jose A. ;
Olanow, C. Warren ;
Poewe, Werner ;
Stern, Matthew .
LANCET NEUROLOGY, 2013, 12 (05) :514-524
12345678910