Density is Density - On the Relation Between Quantity of T-Type Ca2+ Channels and Neuronal Electrical Behavior

被引：16
作者：
Chorev, E. [1 ,2 ]
Manor, Y. [3 ,4 ]
Yarom, Y. [1 ,2 ]
机构：
[1] Hebrew Univ Jerusalem, Interdisciplinary Ctr Computat Neurosci, IL-91904 Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Dept Neurosci, IL-91904 Jerusalem, Israel
[3] Ben Gurion Univ Negev, Dept Life Sci, IL-84105 Beer Sheva, Israel
[4] Ben Gurion Univ Negev, Zlotowski Ctr Neurosci, IL-84105 Beer Sheva, Israel
来源：
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2006年 / 5卷 / 06期
关键词：
Oscillation; T-type channels; rhythm; density; neuronal dynamics; inferior olive;
D O I：
10.2174/187152706779025517
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The electroresponsiveness fingerprint of a neuron reflects the types and distributions of the ionic channels that are embedded in the neuronal membrane as well as its morphology. Theoretical analysis shows that subtle changes in the density of channels can contribute substantially to the electroresponsive fingerprints of neurons. We have confirmed these predictions, using the dynamic clamp approach to emulate changes in channels' densities in neurons from the inferior olive. We demonstrate how the density of T-type channels determines the behavioral destiny of neurons. We argue that regulation of channel densities could be an efficient mechanism for controlling the electrical activity of single cells, as well as the output of neuronal networks.
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页码：655 / 662
页数：8
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