TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib

被引：555

作者：

Wu, Dandan ^{[1
,2
]}

Yang, Xuexian O. ^{[1
]}

机构：

[1] Univ New Mexico, Sch Med, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA

[2] Hunan Agr Univ, Coll Agron, Changsha 410128, Hunan, Peoples R China

来源：

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION | 2020年 / 53卷 / 03期

关键词：

COVID-19; SARS-CoV-2; Cytokine storm; TH17; JAK2; inhibitor;

D O I：

10.1016/j.jmii.2020.03.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

COVID-19 emerges as a pandemic disease with high mortality. Development of effective prevention and treatment is an urgent need. We reviewed TH17 responses in patients with SARS-CoV-2 and proposed an FDA approved JAK2 inhibitor Fedratinib for reducing mortality of patients with TH17 type immune profiles. Copyright (C) 2020, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.

引用

页码：368 / 370

页数：3

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