Analysis of Rab GTPase and GTPase-activating protein function at primary cilia

被引：6

作者：

Yoshimura, Shin-ichiro ^{[1
]}

Haas, Alexander K. ^{[1
]}

Barr, Francis A. ^{[1
]}

机构：

[1] Univ Liverpool, Canc Res Ctr, Liverpool L69 3BX, Merseyside, England

来源：

SMALL GTPASES IN DISEASE, PT B | 2008年 / 439卷

关键词：

D O I：

10.1016/S0076-6879(07)00426-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Primary cilia are sensory structures on the cell surface whose formation requires tight integration of microtubutes and polarized membrane trafficking events. Rabs are GTP-binding proteins of the Ras superfamily that control directed membrane trafficking by regulating membrane-membrane and membrane-cytoskeleton interactions. This chapter describes cell biological and biochemical methods for the analysis of Rab function and Rab GTPase-activating proteins during primary cilia formation.

引用

页码：353 / 364

页数：12

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