Silver-catalyzed cyclopropanation of alkenes with alkynyl N-nosylhydrazones leading to alkynyl cyclopropanes

被引：12

作者：

Ning, Yongquan ^{[1
]}

Huo, Mengtian ^{[1
]}

Wu, Lizuo ^{[1
]}

Bi, Xihe ^{[1
,2
]}

机构：

[1] Northeast Normal Univ, Dept Chem, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Changchun 130024, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 21期

关键词：

TERMINAL ALKYNES; RING; INSERTION; BONDS; ALKYNYLCYCLOPROPANES; DERIVATIVES; COMPLEXES; CARBENES; ALLENES; SI;

D O I：

10.1039/d2cc00099g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, a novel method for the stereoselective synthesis of alkynyl cyclopropanes, by the silver-catalyzed alkynylcyclopropanation of alkenes using alkynyl N-nosylhydrazones as alkynyl carbene precursors, is reported. This method provides a straightforward and powerful approach for preparing various alkynyl cyclopropanes in high yield with excellent stereoselectivities. In addition, the practicality of this method was demonstrated by gram-scale synthesis and late-stage modification of bioactive molecules.

引用

页码：3485 / 3488

页数：4

共 45 条

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