STAT3 is a key transcriptional regulator of cancer stem cell marker CD133 in HCC

被引：30

作者：

Ghoshal, Sarani ^{[1
]}

Fuchs, Bryan C. ^{[1
]}

Tanabe, Kenneth K. ^{[1
]}

机构：

[1] Harvard Med Sch, Div Surg Oncol, Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02115 USA

来源：

HEPATOBILIARY SURGERY AND NUTRITION | 2016年 / 5卷 / 03期

关键词：

CD133; hepatocellular carcinoma (HCC); signal transducer and activator of transcription factor 3 (STAT3); interleukin-6 (IL-6); HEPATOCELLULAR-CARCINOMA; PATHWAY; SIGNAL;

D O I：

10.21037/hbsn.2016.03.02

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Cancer stem cell (CSC) marker CD133 was found to be upregulated in many cancers including hepatocellular carcinoma (HCC). However, the molecular mechanism of CD133 regulation in the liver tumor microenvironment has remained elusive. In this study Won and colleagues report that interleukin-6 (IL-6) mediated signal transducer and activator of transcription factor 3 (STAT3) signaling and hypoxia enhance the expression of CD133 and promote the progression of HCC.

引用

页码：201 / 203

页数：3

共 8 条

[1] A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis [J].

Gujral, Taranjit S. ;

Chan, Marina ;

Peshkin, Leonid ;

Sorger, Peter K. ;

Kirschner, Marc W. ;

MacBeath, Gavin .

CELL, 2014, 159 (04) :844-856

[2] CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway [J].

Ma, S. ;

Lee, T. K. ;

Zheng, B-J ;

Chan, K. W. ;

Guan, X-Y .

ONCOGENE, 2008, 27 (12) :1749-1758

[3] Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty [J].

Magee, Jeffrey A. ;

Piskounova, Elena ;

Morrison, Sean J. .

CANCER CELL, 2012, 21 (03) :283-296

[4] Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells [J].

Wan, Shanshan ;

Zhao, Ende ;

Kryczek, Ilona ;

Vatan, Linda ;

Sadovskaya, Anna ;

Ludema, Gregory ;

Simeone, Diane M. ;

Zou, Weiping ;

Welling, Theodore H. .

GASTROENTEROLOGY, 2014, 147 (06) :1393-1404

[5] Impaired hepatic removal of interleukin-6 in patients with liver cirrhosis [J].

Wiest, Reiner ;

Weigert, Johanna ;

Wanninger, Josef ;

Neumeier, Markus ;

Bauer, Sabrina ;

Schmidhofer, Sandra ;

Farkas, Stefan ;

Scherer, Marcus N. ;

Schaeffler, Andreas ;

Schoelmerich, Juergen ;

Buechler, Christa .

CYTOKINE, 2011, 53 (02) :178-183

[6] Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma [J].

Won, Cheolhee ;

Kim, Byung-Hak ;

Yi, Eun Hee ;

Choi, Kyung-Ju ;

Kim, Eun-Kyung ;

Jeong, Jong-Min ;

Lee, Jae-Ho ;

Jang, Ja-June ;

Yoon, Jung-Hwan ;

Jeong, Won-Il ;

Park, In-Chul ;

Kim, Tae Woo ;

Bae, Sun Sik ;

Factor, Valentina M. ;

Ma, Stephanie ;

Thorgeirsson, Snorri S. ;

Lee, Yun-Han ;

Ye, Sang-Kyu .

HEPATOLOGY, 2015, 62 (04) :1160-1173

[7] Cancer stem cells in the development of liver cancer [J].

Yamashita, Taro ;

Wang, Xin Wei .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (05) :1911-1918

[8] CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity [J].

Yin, Shengyong ;

Li, Jinjun ;

Hu, Chen ;

Chen, Xinhua ;

Yao, Ming ;

Yan, Mingxia ;

Jiang, Guoping ;

Ge, Chao ;

Xie, Haiyang ;

Wan, Dafang ;

Yang, Shengli ;

Zheng, Shusen ;

Gu, Jianren .

INTERNATIONAL JOURNAL OF CANCER, 2007, 120 (07) :1444-1450

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