SHMT2 promotes tumor growth through VEGF and MAPK signaling pathway in breast cancer

被引:3
|
作者
Xie, Shuang-Yan [1 ,2 ]
Shi, Ding-Bo [3 ]
Ouyang, Yi [1 ]
Lin, Fei [1 ]
Chen, Xiao-Yu [1 ]
Jiang, Tong-Chao [1 ]
Xia, Wen [1 ]
Guo, Ling [4 ]
Lin, Huan-Xin [1 ]
机构
[1] Sun Yat Sen Univ, Dept Radiotherapy,Canc Ctr, Collaborat Innovat Ctr Canc Med,State Key Lab Onc, Guangdong Key Lab Nasopharyngeal Carcinoma Diag &, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China
[2] Guangzhou Univ Chinese Med, Dept Radiat Oncol, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Dept Expt Res, State Key Lab Oncol South China,Canc Ctr, Guangzhou, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med,Dept Nasopharynge, State Key Lab Oncol South China,Canc Ctr, Guangdong Key Lab Nasopharyngeal Carcinoma Diag &, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China
来源
AMERICAN JOURNAL OF CANCER RESEARCH | 2022年 / 12卷 / 07期
基金
中国国家自然科学基金;
关键词
SHMT2; breast cancer; serine/glycine metabolism; VEGF; MAPK; HYDROXYMETHYLTRANSFERASE; 2; SHMT2; SERINE; MITOCHONDRIAL; METABOLISM; MECHANISMS; APOPTOSIS; CELLS; PEDF;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancer cells modulate their metabolic activities to adapt to their growth and proliferation. Despite advances in breast cancer biology having led to the widespread use of molecular targeted therapy and hormonal drugs, the molecular mechanisms in metabolism related to the regulation of breast cancer cell proliferation are still poorly understood. Here, we investigate the possible role of SHMT2, a key enzyme in serine metabolism, in breast cancer. Firstly, SHMT2 is found highly expressed in both breast cancer cells and tissues, and patients with high expression of SHMT2 have a worse prognosis. Moreover, the intervention of SHMT2 by either knockdown or over-expression in vitro induces the effect on breast cancer proliferation. Mechanistically, RNA-seq shows that over-expression of SHMT2 affect multiple signaling pathways and biological process in breast cancer cells. Furthermore, we confirm that SHMT2 promotes breast cancer cell growth through MAPK and VEGF signaling pathways. Finally, we verify the role of SHMT2 in promoting breast cancer growth in the xenograft tumor model. Our results indicate that SHMT2 plays a critical role in regulating breast cancer growth through MAPK, and VEGF signaling pathways, and maybe serve as a therapeutic target for breast cancer therapy.
引用
收藏
页码:3405 / +
页数:18
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