Expression of brain-derived neurotrophic factor (BDNF) and its naturally occurring antisense in breast cancer samples

被引：7

作者：

Esfahani, Zahra Taherian ^{[1
]}

Dashti, Sepideh ^{[1
]}

Taheri, Mohammad ^{[3
]}

Kholghi-Oskooei, Vahid ^{[1
]}

Arsang-Jang, Shahram ^{[2
]}

Ghafouri-Fard, Soudeh ^{[1
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran

[2] Qom Univ Med Sci, CRDU, Qom, Iran

[3] Shahid Beheshti Univ Med Sci, Student Res Comm, Tehran, Iran

来源：

META GENE | 2019年 / 19卷

关键词：

BDNF; BDNF-AS; Breast cancer; AGE;

D O I：

10.1016/j.mgene.2018.10.012

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: The brain-derived neurotrophic factor (BDNF) has been implicated in the pathology of CNS disorders as well as cancer. A long non-coding RNA has been distinguished that is transcribed from the anti-sense (AS) strand of BDNF locus. Method: We evaluated expression of BDNF and BDNF-AS in breast cancer and adjacent non-cancerous tissues (ANCTs) using real-time PCR technique. Result: Expression of BDNF-AS was associated with both tumor grade and mitotic rate. BDNF expression was significantly lower in estrogen receptor (ER) positive samples compared with ER negative samples. Moreover, significant pairwise correlations were found between expressions of these genes in both tumoral tissues and ANCTs. Conclusion: We provided evidences for participation of BDNF and its naturally occurring anti-sense in the pathogenesis of breast cancer.

引用

页码：69 / 73

页数：5

共 21 条

[1] TrkC:: A new predictive marker in breast cancer? [J].

Blasco-Gutierrez, Maria Jesus ;

Jose-Crespo, Isabel Julia San ;

Zozaya-Alvarez, Enrique ;

Ramos-Sanchez, Rafael ;

Garcia-Atares, Natividad .

CANCER INVESTIGATION, 2007, 25 (06) :405-410

[2] Serum concentrations of brain-derived neurotrophic factor (BDNF) are decreased in colorectal cancer patients [J].

Brierley, G. V. ;

Priebe, I. K. ;

Purins, L. ;

Fung, K. Y. C. ;

Tabor, B. ;

Lockett, T. ;

Nice, E. ;

Gibbs, P. ;

Tie, J. ;

McMurrick, P. ;

Moore, J. ;

Ruszkiewicz, A. ;

Burgess, A. ;

Cosgrove, L. J. .

CANCER BIOMARKERS, 2013, 13 (02) :67-73

[3] The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease [J].

Budni, Josiane ;

Bellettini-Santos, Tatiani ;

Mina, Francielle ;

Garcez, Michelle Lima ;

Zugno, Alexandra Ioppi .

AGING AND DISEASE, 2015, 6 (05) :331-341

[4] brms: An R Package for Bayesian Multilevel Models Using Stan [J].

Buerkner, Paul-Christian .

JOURNAL OF STATISTICAL SOFTWARE, 2017, 80 (01) :1-28

[5] Expression of BDNF and trkB as a function of age and cognitive performance [J].

Croll, SD ;

Ip, NY ;

Lindsay, RM ;

Wiegand, SJ .

BRAIN RESEARCH, 1998, 812 (1-2) :200-208

[6] Regulatory roles of natural antisense transcripts [J].

Faghihi, Mohammad Ali ;

Wahlestedt, Claes .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (09) :637-643

[7] Neurotrophin signal transduction in the nervous system [J].

Kaplan, DR ;

Miller, FD .

CURRENT OPINION IN NEUROBIOLOGY, 2000, 10 (03) :381-391

[8] Hypothalamic Gene Transfer of BDNF Inhibits Breast Cancer Progression and Metastasis in Middle Age Obese Mice [J].

Liu, Xianglan ;

McMurphy, Travis ;

Xiao, Run ;

Slater, Andrew ;

Huang, Wei ;

Cao, Lei .

MOLECULAR THERAPY, 2014, 22 (07) :1275-1284

[9] Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation [J].

Modarresi, Farzaneh ;

Faghihi, Mohammad Ali ;

Lopez-Toledano, Miguel A. ;

Fatemi, Roya Pedram ;

Magistri, Marco ;

Brothers, Shaun P. ;

van der Brug, Marcel P. ;

Wahlestedt, Claes .

NATURE BIOTECHNOLOGY, 2012, 30 (05) :453-+

[10] Brain-derived neurotrophic factor expression predicts adverse pathological & clinical outcomes in human breast cancer [J].

Patani, Neill ;

Jiang, Wen G. ;

Mokbel, Kefah .

CANCER CELL INTERNATIONAL, 2011, 11

← 1 2 3 →