Iodine(III)-Mediated Selective Intermolecular C-H Amination for the Chemical Diversification of Tryptamines

被引：15

作者：

Bosnidou, Alexandra E. ^{[1
]}

Millan, Alba ^{[1
]}

Ceballos, Javier ^{[1
]}

Martinez, Claudio ^{[1
]}

Muniz, Kilian ^{[1
,2
]}

机构：

[1] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Ave Paisos Catalans 16, E-43007 Tarragona, Spain

[2] ICREA, Passeig Lluis Co 23, Barcelona 08010, Spain

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 15期

关键词：

METAL-FREE CONDITIONS; UNSYMMETRICAL LAMBDA(3)-IODANES; OXIDATIVE AMINATION; ORGANIC-SYNTHESIS; MEDIATED REACTION; INDOLE SYNTHESIS; BOND ACTIVATION; IODINE; REAGENTS; DIAMINATION;

D O I：

10.1021/acs.joc.6b01118

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Defined hypervalent iodine reagents of the general structure PhI[N(SO2R)(SO2R'](2) promote the selective direct C-H-amination of the indole core of various tryptamines. Starting from a general C2-amination strategy, subsequent transformations enable a variety of site-selective functionalizations, which proceed with noteworthy high chemoselectivity and provide an overall access to structurally diversified products.

引用

收藏

页码：6496 / 6504

页数：9

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