Wavelength specific activation of PI 3-kinase by UVB irradiation

被引：25

作者：

Kabuyama, Y ^{[1
]}

Hamaya, M ^{[1
]}

Homma, Y ^{[1
]}

机构：

[1] Fukushima Med Coll, Inst Biomed Sci, Dept Biomol Sci, Fukushima 9601295, Japan

来源：

FEBS LETTERS | 1998年 / 441卷 / 02期

关键词：

ultraviolet B; phosphatidylinositol; 3-kinase; cell death; tyrosine kinase; reactive oxygen intermediate;

D O I：

10.1016/S0014-5793(98)01565-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effect of UVB irradiation on phospholipid metabolism using normal human diploid skin fibroblasts, When cells were exposed to monochromatic UV Light, the intracellular PIP3 level was increased within 1 min in a wavelength-specific manner. The increase was most marked in the UVB range and was inhibited by a PI 3-kinase inhibitor, tyrosine kinase inhibitor, or antioxidant reagents. Furthermore, the decrease of cell viability induced by UVB irradiation was significantly blocked by wortmannin. These results suggest that PI 3-kinase activation is involved in novel cellular responses specific for UVB that lead to cell death. (C) 1998 Federation of European Biochemical Societies.

引用

页码：297 / 301

页数：5

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