Leptin and adiponectin in obese and non-obese subjects with asthma

被引：32
|
作者：
Lessard, Andrea [1 ]
St-Laurent, Julie [1 ]
Turcotte, Helene [1 ]
Boulet, Louis-Philippe [1 ]
机构：
[1] Ctr Rech Clin Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada
来源：
BIOMARKERS | 2011年 / 16卷 / 03期
关键词：
Asthma; leptin; adiponectin; obese asthmatics; AIRWAY INFLAMMATION; ASSOCIATION; CHILDREN;
D O I：
10.3109/1354750X.2010.550013
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Objective: To understand the role of leptin and adiponectin in obese asthmatics. Methods: We compared serum leptin, adiponectin and sputum leptin levels in 44 non-obese and 44 obese subjects. Results: We found higher serum leptin (P < 0.0001) and lower adiponectin (P = 0.0002) levels in obese asthmatics. Sputum leptin was correlated with body mass index (BMI; r = 0.34, P = 0.03) and serum leptin (r = 0.43, P = 0.005); however, this last correlation was not significant after adjusting for BMI (r = 0.26, P = 0.11). Conclusion: Airway inflammation in obese asthmatics may present a different pattern involving leptin. Sputum leptin levels may partially originate from systemic circulation, with other contributing mechanisms.
引用
收藏
页码：271 / 273
页数：3
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