Hearing loss is associated with cortical thinning in cognitively normal older adults

被引：16

作者：

Ha, J. ^{[1
,2
,3
]}

Cho, Y. S. ^{[4
]}

Kim, S. J. ^{[1
,2
,3
,5
,6
]}

Cho, S. H. ^{[1
,2
,3
,7
]}

Kim, J. P. ^{[1
,2
,3
]}

Jung, Y. H. ^{[1
,2
,3
,8
]}

Jang, H. ^{[1
,2
,3
]}

Shin, H. -Y. ^{[9
]}

Lin, F. R. ^{[10
,11
,12
,13
]}

Na, D. L. ^{[1
,2
,3
,14
,15
,16
]}

Seo, S. W. ^{[1
,2
,3
,16
]}

Moon, I. J. ^{[4
]}

Kim, H. J. ^{[1
,2
,3
,14
,17
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, 50 Ilwon Dong, Seoul 135710, South Korea

[2] Samsung Med Ctr, Samsung Alzheimer Res Ctr, Seoul, South Korea

[3] Samsung Med Ctr, Neurosci Ctr, Seoul, South Korea

[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea

[5] Gyeongsang Natl Univ, Dept Neurol, Sch Med, Chang Won, South Korea

[6] Gyeongsang Natl Univ, Changwon Hosp, Chang Won, South Korea

[7] Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Neurol, Med Sch, Gwangju, South Korea

[8] Hanyang Univ, Myongji Hosp, Dept Neurol, Goyang, South Korea

[9] Sungkyunkwan Univ, Ctr Hlth Promot, Samsung Med Ctr, Sch Med, Seoul, South Korea

[10] Johns Hopkins Univ, Dept Otolaryngol, Baltimore, MD USA

[11] Johns Hopkins Univ, Dept Med, Baltimore, MD USA

[12] Johns Hopkins Univ, Dept Mental Hlth, Baltimore, MD USA

[13] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA

[14] Sungkyunkwan Univ, Dept Hlth Sci & Technol, SAIHST, Seoul, South Korea

[15] Samsung Med Ctr, Stem Cell & Regenerat Med Inst, Seoul, South Korea

[16] Sungkyunkwan Univ, SAIHST, Dept Clin Res Design & Evaluat, Seoul, South Korea

[17] Sungkyunkwan Univ, Dept Digital Hlth, SAIHST, Seoul, South Korea

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2020年 / 27卷 / 06期

关键词：

cognitively normal; cortical thickness; hearing loss; AUDITORY-CORTEX; AGE; BRAIN; REGISTRATION; IMPAIRMENT; PATHWAY; GENDER;

D O I：

10.1111/ene.14195

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and purpose Hearing loss (HL) is one of the most influential risk factors of dementia in older adults. However, its potential association with neurodegeneration is not well established. The association between HL and cortical thickness in cognitively normal older adults was evaluated. Methods In all, 982 cognitively normal older adults (age >= 65 years) were identified from the Health Promotion Center at the Samsung Medical Center from September 2008 to December 2014. The participants underwent pure-tone audiometry and brain magnetic resonance imaging. HL was evaluated according to a four-frequency (0.5, 1, 2, 4 kHz) pure-tone average. Participants were divided into three groups according to pure-tone average (normal hearing <= 15 dB, minimal HL 16-25 dB, mild-to-severe HL >25 dB). Cortical thickness in the HL groups was compared with that of the normal hearing group. Results In women, right ear HL was associated with cortical thinning: the minimal HL group showed cortical thinning in the left frontal and bilateral occipital areas and the mild-to-severe HL group showed cortical thinning in the bilateral frontal, right temporal and bilateral occipital areas compared to the normal hearing group. In men, there was no significant association between HL on either side and cortical thickness. Conclusion In older women, right ear HL is associated with neurodegeneration even in a cognitively normal state. Therefore, managing HL especially in older women may be an effective strategy for dementia prevention.

引用

页码：1003 / 1009

页数：7

共 32 条

[1] Diffusion tensor imaging shows white matter tracts between human auditory and visual cortex [J].