Hypothalamic -pituitary -adrenal axis -related genes and cognition in major mood disorders and schizophrenia: a systematic review

被引：18
作者：
Ferrer, Alex [1 ,2 ]
Labad, Javier [1 ,3 ,4 ]
Salvat-Pujol, Neus [1 ,2 ,3 ,4 ]
Monreal, Jose A. [1 ,3 ,4 ]
Urretavizcaya, Mikel [2 ,3 ,5 ]
Crespo, Jose M. [2 ,3 ,5 ]
Menchon, Jose M. [2 ,3 ,5 ]
Palao, Diego [1 ,3 ,4 ]
Soria, Virginia [2 ,3 ,5 ]
机构：
[1] Parc Tauli Hosp Univ, Inst Invest & Innovacio Parc Tauli I3PT, Dept Mental Hlth, Sabadell, Spain
[2] Univ Barcelona, Dept Clin Sci, Barcelona, Spain
[3] Carlos III Hlth Inst, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
[4] Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Barcelona, Spain
[5] Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Neurosci Grp Psychiat & Mental Hlth, Dept Psychiat, Barcelona, Spain
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2020年 / 101卷
关键词：
Hypothalamic-pituitary-adrenal axis; Cognition; Major depressive disorder; Bipolar disorder; Schizophrenia; Genetics; POSTTRAUMATIC-STRESS-DISORDER; GLUCOCORTICOID-RECEPTOR GENE; EARLY-LIFE STRESS; GENOME-WIDE ASSOCIATION; CRF-BINDING-PROTEIN; HPA-AXIS; CHILDHOOD MALTREATMENT; FKBP5; POLYMORPHISMS; EMOTIONAL NEGLECT; WORKING-MEMORY;
D O I：
10.1016/j.pnpbp.2020.109929
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Hypothalamic-pituitary-adrenal (HPA) axis dysregulation and cognitive deficits are two well-characterized endophenotypes present in different serious mental illnesses (SMIs), including major depressive disorder, bipolar disorder and schizophrenia. Our aim was to study the influence of genetic and epigenetic variations in HPA axis-related genes on cognitive performance in clinical samples, including patients with major mood disorders and schizophrenia. A systematic search was performed using PubMed (Medline), PsycINFO and Scopus databases. The systematic review identified 12 studies dealing with HPA-related genes and cognition in samples including patients with SMIs, focusing on single nucleotide polymorphism (SNP) variants, while no studies analysing epigenetic variations were found. The results suggest different and specific effects on the cognitive performance of SNP variants in the HPA axis-related genes studied, as well as interactions with traumatic experiences. There was high heterogeneity in the studied samples, genes analysed, and cognitive tasks evaluated. The relationship between HPA-related genes and cognition in SMIs is still largely unknown, and further studies including larger samples and epigenetic variations are needed.
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页数：11
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