Functional recovery after brain lesion - contralateral neuromodulation: an fMRI study

被引：62

作者：

Abo, M

Chen, ZG

Lai, LJ

Reese, T

Bjelke, B ^{[1
]}

机构：

[1] Karolinska Inst, Dept Clin Neurosci, S-17176 Stockholm, Sweden

[2] Jikei Univ, Sch Med, Dept Rehabil Med, Komae, Tokyo 201, Japan

来源：

NEUROREPORT | 2001年 / 12卷 / 07期

关键词：

functional recovery; MRI; necrotic lesion; plasticity; sensorimotor cortex;

D O I：

10.1097/00001756-200105250-00048

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Behavioral recovery takes place even after permanent damage to the entire brain region normally controlling sensorimotor hind limb function in the rat. In our study, 2 weeks after full behavioral recovery from an experimental unilateral permanent brain damage, the topographic representation of the previous paretic hindlimb was investigated by fMRI. The analysis showed that during electrical stimulation of the previously paretic hindlimb, two normally inactive brain regions were now being activated. One region was the non-damaged contralateral sensori-motor cortex and the other region was located lateral to the lesion. These results suggest that behavioral recovery can be explained by functional reorganization and neuromodulation of the brain. NeuroReport 12:1543-1547 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：1543 / 1547

页数：5

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