Synthesis of novel and stable 5-aminolevulinic acid derivatives for the efficient synthesis of 5-aminolevulinic acid based prodrugs

被引：10

作者：

Vallinayagam, Ramakrishnan ^{[1
]}

Bertschy, Hugo ^{[2
]}

Berger, Yann ^{[3
]}

Wenger, Virginie ^{[1
]}

Neier, Reinhard ^{[1
]}

机构：

[1] Univ Neuchatel, Inst Chim, CH-2009 Neuchatel, Switzerland

[2] F Hoffmann La Roche & Cie AG, CH-4070 Basel, Switzerland

[3] Lab Cantonal Control Denres Aliment, CH-1066 Epalinges, Switzerland

来源：

SYNTHESIS-STUTTGART | 2007年 / 23期

关键词：

amino acid; activated ester; protecting group; prodrug; porphyrin;

D O I：

10.1055/s-2007-990825

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient synthesis of two stable, easily handled precursors of 5-aminolevulinate is reported. These precursors are stable to the chemical transformation needed for the synthesis of bioconjugates and can be readily deprotected in good yields.

引用

页码：3731 / 3735

页数：5

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