Cyclodextrins as Anti-inflammatory Agents: Basis, Drugs and Perspectives

被引：31

作者：

Appleton, Silvia Lucia ^{[1
]}

Navarro-Orcajada, Silvia ^{[2
]}

Martinez-Navarro, Francisco Juan ^{[3
,4
]}

Caldera, Fabrizio ^{[1
]}

Lopez-Nicolas, Jose Manuel ^{[2
]}

Trotta, Francesco ^{[1
]}

Matencio, Adrian ^{[1
]}

机构：

[1] Univ Torino, Dip Chim, Via P Giuria 7, I-10125 Turin, Italy

[2] Univ Murcia, Fac Vet, Unidad Docente Biol, Dept Bioquim & Biol Mol A, Reg Campus Int Excellence,Campus Mare Nostrum, Murcia 30100, Spain

[3] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA

[4] Albert Einstein Coll Med, Dept Med Hepatol, Bronx, NY 10461 USA

来源：

BIOMOLECULES | 2021年 / 11卷 / 09期

关键词：

cyclodextrins; inflammation; drug; review; bioactivity; HYDROXYPROPYL-BETA-CYCLODEXTRIN; APPENDED ALPHA-CYCLODEXTRIN; NF-KAPPA-B; DEXAMETHASONE-CYCLODEXTRIN; INDUCED INFLAMMATION; INCLUSION COMPLEX; ESSENTIAL OIL; ANIMAL-MODEL; DISEASE; NANOSPONGES;

D O I：

10.3390/biom11091384

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammation is a biological response of the immune system to harmful stimuli. Importantly, inflammation is also a hallmark of several human diseases such as cancer or diabetes. Novel drugs to treat this response are constantly researched, but the formulation is usually forgotten. Cyclodextrins (CDs) are a well-known excipient for complexing and drug delivery. Anti-inflammatory drugs and bioactive compounds with similar activities have been favored from these CD processes. CDs also illustrate anti-inflammatory activity per se. This review tried to describe the capacities of CDs in this field, and is divided into two parts: Firstly, a short description of the inflammation disease (causes, symptoms, treatment) is explained; secondly, the effects of different CDs alone or forming inclusion complexes with drugs or bioactive compounds are discussed.

引用

页数：15

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