Differential induction of interleukin-I β mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharides

被引：19

作者：

Tonelli, LH ^{[1
]}

Maeda, S ^{[1
]}

Rapp, KL ^{[1
]}

Sternberg, EM ^{[1
]}

机构：

[1] NIMH, Sect Neuroendocrine Immunol & Behav, NIH, DHHS, Bethesda, MD 20892 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 140卷 / 1-2期

关键词：

hypothalamus; circumventricular organs; cerebral cortex; cytokines; inbred rats;

D O I：

10.1016/S0165-5728(03)00171-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The expression of interleukin-1 beta (IL-1beta) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 It after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and choroid plexus. At 12 It after LPS administration, increased IL-1beta mRNA expression was detected in the hypothalamus of LEW/N rats. In contrast, increased IL-1beta mRNA expression was detected in the cerebral cortex of F344/N rats. These data show region-specific differences of IL-1beta mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation. Published by Elsevier B.V.

引用

页码：126 / 136

页数：11

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