A gut feeling about stroke reveals gut-brain axis' active role in homeostasis and dysbiosis

被引：26

作者：

Bonsack, Brooke ^{[1
]}

Jiang, Rays H. Y. ^{[2
]}

Borlongan, Cesar, V ^{[1
]}

机构：

[1] Univ S Florida, Morsani Coll Med, Dept Neurosurg & Brain Repair, 12901 Bruce B Downs Blvd, Tampa, FL 33612 USA

[2] Univ S Florida, USF Genom Program, Coll Publ Hlth, Global & Planetary Hlth, Tampa, FL 33620 USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2020年 / 40卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Cerebral ischemia; gastrointestinal tract; central nervous system; peripheral nervous system; inflammation; microbiome; stem cells;

D O I：

10.1177/0271678X19900037

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peripheral inflammatory responses accompany many neurological disorders, including stroke. The gut-brain axis opens new avenues in our understanding of stroke progression and abrogation of secondary cell death. Certain microbiomes, especially those related to inflammation, appear to closely reflect the homeostasis and dysbiosis of both the brain and the gut, suggesting their potential application as biomarkers and therapeutic targets. A paradigm shift from purely central towards incorporating peripheral sequestration of cell death pathways may improve stroke therapeutic outcomes. Recognizing this gut-brain axis as key to disease pathology and treatment is likely to usher innovative approaches in cell-based regenerative medicine for stroke.

引用

页码：1132 / 1134

页数：3

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