Targeting the chemokine receptor CXCR3 and its ligand CXCL10 in the central nervous system: Potential therapy for inflammatory demyelinating disease?

被引：22
作者：
Sorensen, TL [1 ]
机构：
[1] Univ Copenhagen, Glostrup Hosp, Dept Neurol, MS Clin, DK-2600 Glostrup, Denmark
来源：
CURRENT NEUROVASCULAR RESEARCH | 2004年 / 1卷 / 02期
关键词：
CXCR3; CXCL10; IP-10; chemokines; chemokine receptors; multiple sclerosis;
D O I：
10.2174/1567202043480143
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Multiple sclerosis is an inflammatory disease of the CNS and a leading cause of disability. Inflammatory mediators play an orchestrating part in lesional development leading to symptoms. Chemokines -chemoattractant cytokines - regulate the inflammatory composite of the MS lesion. This review focuses on the present data regarding CXCL10 (previously known as IP-10) and CXRC3 in multiple sclerosis, since consistent data has suggested that this chemokine/chemokine receptor pair has a pivotal role in leukocyte recruitment into the central nervous system (CNS) in multiple sclerosis.
引用
收藏
页码：183 / 190
页数：8
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